Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study
ABSTRACT BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients’ geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of p...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Paulista de Medicina
|
| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000600535&lng=en&tlng=en |
| _version_ | 1818024830763532288 |
|---|---|
| author | Rayana Taques Posselt Vinícius Nicolelli Coelho Danieli Cristina Pigozzo Marcela Idalia Guerrer Marília da Cruz Fagundes Renato Nisihara Thelma Larocca Skare |
| author_facet | Rayana Taques Posselt Vinícius Nicolelli Coelho Danieli Cristina Pigozzo Marcela Idalia Guerrer Marília da Cruz Fagundes Renato Nisihara Thelma Larocca Skare |
| author_sort | Rayana Taques Posselt |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients’ geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND SETTING: Cross-sectional observational study in a rheumatology unit. METHODS: 301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes. RESULTS: There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed: P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated. CONCLUSION: SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment. |
| first_indexed | 2024-12-10T04:06:27Z |
| format | Article |
| id | doaj.art-dfb759c9148c47a9a243672b4a61b944 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-10T04:06:27Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-dfb759c9148c47a9a243672b4a61b9442022-12-22T02:02:50ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460135653554010.1590/1516-3180.2017.0089110617S1516-31802017000600535Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional studyRayana Taques PosseltVinícius Nicolelli CoelhoDanieli Cristina PigozzoMarcela Idalia GuerrerMarília da Cruz FagundesRenato NisiharaThelma Larocca SkareABSTRACT BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients’ geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND SETTING: Cross-sectional observational study in a rheumatology unit. METHODS: 301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes. RESULTS: There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed: P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated. CONCLUSION: SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000600535&lng=en&tlng=enThyroidAutoimmunityRheumatic disease. |
| spellingShingle | Rayana Taques Posselt Vinícius Nicolelli Coelho Danieli Cristina Pigozzo Marcela Idalia Guerrer Marília da Cruz Fagundes Renato Nisihara Thelma Larocca Skare Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study São Paulo Medical Journal Thyroid Autoimmunity Rheumatic disease. |
| title | Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study |
| title_full | Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study |
| title_fullStr | Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study |
| title_full_unstemmed | Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study |
| title_short | Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study |
| title_sort | prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases cross sectional study |
| topic | Thyroid Autoimmunity Rheumatic disease. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000600535&lng=en&tlng=en |
| work_keys_str_mv | AT rayanataquesposselt prevalenceofthyroidautoantibodiesinpatientswithsystematicautoimmunerheumaticdiseasescrosssectionalstudy AT viniciusnicolellicoelho prevalenceofthyroidautoantibodiesinpatientswithsystematicautoimmunerheumaticdiseasescrosssectionalstudy AT danielicristinapigozzo prevalenceofthyroidautoantibodiesinpatientswithsystematicautoimmunerheumaticdiseasescrosssectionalstudy AT marcelaidaliaguerrer prevalenceofthyroidautoantibodiesinpatientswithsystematicautoimmunerheumaticdiseasescrosssectionalstudy AT mariliadacruzfagundes prevalenceofthyroidautoantibodiesinpatientswithsystematicautoimmunerheumaticdiseasescrosssectionalstudy AT renatonisihara prevalenceofthyroidautoantibodiesinpatientswithsystematicautoimmunerheumaticdiseasescrosssectionalstudy AT thelmalaroccaskare prevalenceofthyroidautoantibodiesinpatientswithsystematicautoimmunerheumaticdiseasescrosssectionalstudy |