Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS
Nocturnal pulse oximetry (NOx) is an alternative diagnostic test for obstructive sleep apnea syndrome (OSAS) in childhood yet with variable diagnostic performance. Our aim was to apply advanced signal analysis to develop novel and more accurate NOx indices. We studied 45 children aged 3–10 years who...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/3/453 |
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| author | Panagiota Pappa Konstantinos Kourelis Anastasios Goulioumis Magdalene Tsiakou Panagiotis Plotas Aris Bertzouanis Ilias Theodorakopoulos Konstantinos Mourtzouchos Michael B. Anthracopoulos Athanasios Asimakopoulos Sotirios Fouzas |
| author_facet | Panagiota Pappa Konstantinos Kourelis Anastasios Goulioumis Magdalene Tsiakou Panagiotis Plotas Aris Bertzouanis Ilias Theodorakopoulos Konstantinos Mourtzouchos Michael B. Anthracopoulos Athanasios Asimakopoulos Sotirios Fouzas |
| author_sort | Panagiota Pappa |
| collection | DOAJ |
| description | Nocturnal pulse oximetry (NOx) is an alternative diagnostic test for obstructive sleep apnea syndrome (OSAS) in childhood yet with variable diagnostic performance. Our aim was to apply advanced signal analysis to develop novel and more accurate NOx indices. We studied 45 children aged 3–10 years who underwent adenotonsillectomy for adenotonsillar hypertrophy and OSAS symptoms. Participants performed NOx before and three months after surgery, and the changes in McGill oximetry score (MOS), oxygen desaturation ≥3% index (ODI3), and the novel parameters—cumulative saturation area (CSA) and oxygen saturation sample entropy (SSE)—were assessed. There was a significant improvement (<i>p</i> < 0.001) in all NOx indices. When pre- and post-adenotonsillectomy NOx recordings were compared, the MOS had an area under the curve (AUC) of 0.811 with 63.2% sensitivity and 100% specificity at a cutoff >1. The AUC of ODI3 was 0.994, with 97.8% sensitivity and 91.1% specificity at a cutoff of >3.6 events per hour. The CSA and SSE had an AUC of 1.00, with 100% sensitivity and specificity at a cutoff of >293 and >0.99, respectively. We conclude that the herein-introduced indices—CSA and SSE—hold promise in improving the diagnostic ability of NOx in children suspected of OSAS. |
| first_indexed | 2024-03-11T06:46:09Z |
| format | Article |
| id | doaj.art-dfb8a4b780fb4a88a65d02cce0df0e26 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T06:46:09Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-dfb8a4b780fb4a88a65d02cce0df0e262023-11-17T10:20:28ZengMDPI AGChildren2227-90672023-02-0110345310.3390/children10030453Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSASPanagiota Pappa0Konstantinos Kourelis1Anastasios Goulioumis2Magdalene Tsiakou3Panagiotis Plotas4Aris Bertzouanis5Ilias Theodorakopoulos6Konstantinos Mourtzouchos7Michael B. Anthracopoulos8Athanasios Asimakopoulos9Sotirios Fouzas10School of Medicine, University of Patras, 26500 Patras, GreeceDepartment of Otorhinolaryngology, ‘Karamandaneio’ Children’s Hospital, 26331 Patras, GreeceDepartment of Otorhinolaryngology, ‘Karamandaneio’ Children’s Hospital, 26331 Patras, GreeceDepartment of Otorhinolaryngology, ‘Karamandaneio’ Children’s Hospital, 26331 Patras, GreeceLaboratory of Primary Health Care, School of Health Rehabilitation Sciences, University of Patras, 26500 Patras, GreecePediatric Pulmonology Research Group, Pediatric Respiratory Unit, University Hospital of Patras, 26504 Patras, GreeceDepartment of Electrical and Computer Engineering, Democritus University of Thrace, 67132 Xanthi, GreeceDepartment of Otorhinolaryngology, ‘Karamandaneio’ Children’s Hospital, 26331 Patras, GreeceSchool of Medicine, University of Patras, 26500 Patras, GreeceDepartment of Otorhinolaryngology, ‘Karamandaneio’ Children’s Hospital, 26331 Patras, GreeceSchool of Medicine, University of Patras, 26500 Patras, GreeceNocturnal pulse oximetry (NOx) is an alternative diagnostic test for obstructive sleep apnea syndrome (OSAS) in childhood yet with variable diagnostic performance. Our aim was to apply advanced signal analysis to develop novel and more accurate NOx indices. We studied 45 children aged 3–10 years who underwent adenotonsillectomy for adenotonsillar hypertrophy and OSAS symptoms. Participants performed NOx before and three months after surgery, and the changes in McGill oximetry score (MOS), oxygen desaturation ≥3% index (ODI3), and the novel parameters—cumulative saturation area (CSA) and oxygen saturation sample entropy (SSE)—were assessed. There was a significant improvement (<i>p</i> < 0.001) in all NOx indices. When pre- and post-adenotonsillectomy NOx recordings were compared, the MOS had an area under the curve (AUC) of 0.811 with 63.2% sensitivity and 100% specificity at a cutoff >1. The AUC of ODI3 was 0.994, with 97.8% sensitivity and 91.1% specificity at a cutoff of >3.6 events per hour. The CSA and SSE had an AUC of 1.00, with 100% sensitivity and specificity at a cutoff of >293 and >0.99, respectively. We conclude that the herein-introduced indices—CSA and SSE—hold promise in improving the diagnostic ability of NOx in children suspected of OSAS.https://www.mdpi.com/2227-9067/10/3/453obstructive sleep apnea syndromesleep-disordered breathingnocturnal oximetry |
| spellingShingle | Panagiota Pappa Konstantinos Kourelis Anastasios Goulioumis Magdalene Tsiakou Panagiotis Plotas Aris Bertzouanis Ilias Theodorakopoulos Konstantinos Mourtzouchos Michael B. Anthracopoulos Athanasios Asimakopoulos Sotirios Fouzas Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS Children obstructive sleep apnea syndrome sleep-disordered breathing nocturnal oximetry |
| title | Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS |
| title_full | Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS |
| title_fullStr | Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS |
| title_full_unstemmed | Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS |
| title_short | Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS |
| title_sort | novel indices to improve the diagnostic ability of nocturnal oximetry in children with osas |
| topic | obstructive sleep apnea syndrome sleep-disordered breathing nocturnal oximetry |
| url | https://www.mdpi.com/2227-9067/10/3/453 |
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