Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X
PurposeCardiac syndrome X (CSX) is a condition with normal coronary angiography but angina pectoris. Chronic inflammation caused by Helicobacter pylori (H. pylori) infection may play a pathogenic role in CSX. Therefore, we conducted a meta-analysis to explore the relationship between H. pylori infec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.823885/full |
| _version_ | 1818529370943258624 |
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| author | Dong-Hong Zhang Chen Yuan Bei-Bei Wang Xin-Jiang Dong Shu-Ping Lv Fei-Hong Li Zhen-Xiu Hou Xiao-Li Liu Kang Chen |
| author_facet | Dong-Hong Zhang Chen Yuan Bei-Bei Wang Xin-Jiang Dong Shu-Ping Lv Fei-Hong Li Zhen-Xiu Hou Xiao-Li Liu Kang Chen |
| author_sort | Dong-Hong Zhang |
| collection | DOAJ |
| description | PurposeCardiac syndrome X (CSX) is a condition with normal coronary angiography but angina pectoris. Chronic inflammation caused by Helicobacter pylori (H. pylori) infection may play a pathogenic role in CSX. Therefore, we conducted a meta-analysis to explore the relationship between H. pylori infection and risk of CSX.MethodsA systematic search in the Web of Science, Medline, Embase and Chinese databases (CNKI and Wanfang) was conducted up to October 2021. Articles on the association between H. pylori infection and the risk of CSX were included and were analyzed by R software (version 4.1.0).ResultsTen case-control studies involving 703 CSX patients and 731 healthy controls were included. H. pylori infection was associated with an increased risk of CSX (OR: 8.29, 95% CI: 4.64–14.82). We also found a significant association in those 25–40 years of age (OR: 1.34, 95% CI: 1.04–1.72), those 40–50 years of age (OR: 11.27, 95% CI: 4.29–29.61), those over 50 years of age (OR: 7.18, 95% CI: 3.59–14.36), those in developing countries [Iran (OR: 12.99, 95% CI: 8.61–19.60) and China (OR: 5.14, 95% CI: 3.09–8.56)]. However, this association was not apparent in a developed country [Italy (OR: 0.93, 95% CI: 0.37–2.33)].ConclusionsOur study suggested a possible association between H. pylori infection and the risk of CSX. Its pathogenicity is stronger in middle-aged individuals and some developing countries. However, more studies are needed to further investigate whether early eradication of H. pylori can reduce the incidence rate of CSX, especially in middle-aged individuals and some developing countries. |
| first_indexed | 2024-12-11T17:06:01Z |
| format | Article |
| id | doaj.art-dfb9211bc30b416782db7f142be5b0fc |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T17:06:01Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-dfb9211bc30b416782db7f142be5b0fc2022-12-22T00:57:42ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.823885823885Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome XDong-Hong Zhang0Chen Yuan1Bei-Bei Wang2Xin-Jiang Dong3Shu-Ping Lv4Fei-Hong Li5Zhen-Xiu Hou6Xiao-Li Liu7Kang Chen8Department of Infection Disease, Shanghai Fifth People's Hospital, Shanghai, ChinaDepartment of Emergency, Shanghai Fengxian District Central Hospital, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, ChinaDepartment of Cardiology, The First People's Hospital of Jinzhong, Jinzhong, ChinaDepartment of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, ChinaDepartment of Cardiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, ChinaDepartment of Cardiology, Yantai Yeda Hospital, Yantai, ChinaDepartment of Cardiology, The First People's Hospital of Jinzhong, Jinzhong, ChinaDepartment of Cardiology, Yun Cheng Central Hospital, Yuncheng, ChinaDepartment of Emergency, Shanghai Fengxian District Central Hospital, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, ChinaPurposeCardiac syndrome X (CSX) is a condition with normal coronary angiography but angina pectoris. Chronic inflammation caused by Helicobacter pylori (H. pylori) infection may play a pathogenic role in CSX. Therefore, we conducted a meta-analysis to explore the relationship between H. pylori infection and risk of CSX.MethodsA systematic search in the Web of Science, Medline, Embase and Chinese databases (CNKI and Wanfang) was conducted up to October 2021. Articles on the association between H. pylori infection and the risk of CSX were included and were analyzed by R software (version 4.1.0).ResultsTen case-control studies involving 703 CSX patients and 731 healthy controls were included. H. pylori infection was associated with an increased risk of CSX (OR: 8.29, 95% CI: 4.64–14.82). We also found a significant association in those 25–40 years of age (OR: 1.34, 95% CI: 1.04–1.72), those 40–50 years of age (OR: 11.27, 95% CI: 4.29–29.61), those over 50 years of age (OR: 7.18, 95% CI: 3.59–14.36), those in developing countries [Iran (OR: 12.99, 95% CI: 8.61–19.60) and China (OR: 5.14, 95% CI: 3.09–8.56)]. However, this association was not apparent in a developed country [Italy (OR: 0.93, 95% CI: 0.37–2.33)].ConclusionsOur study suggested a possible association between H. pylori infection and the risk of CSX. Its pathogenicity is stronger in middle-aged individuals and some developing countries. However, more studies are needed to further investigate whether early eradication of H. pylori can reduce the incidence rate of CSX, especially in middle-aged individuals and some developing countries.https://www.frontiersin.org/articles/10.3389/fcvm.2022.823885/fullHelicobacter pylori infectionCardiac syndrome Xcytotoxin-associated gene Ameta-analysissystematic review |
| spellingShingle | Dong-Hong Zhang Chen Yuan Bei-Bei Wang Xin-Jiang Dong Shu-Ping Lv Fei-Hong Li Zhen-Xiu Hou Xiao-Li Liu Kang Chen Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X Frontiers in Cardiovascular Medicine Helicobacter pylori infection Cardiac syndrome X cytotoxin-associated gene A meta-analysis systematic review |
| title | Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X |
| title_full | Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X |
| title_fullStr | Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X |
| title_full_unstemmed | Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X |
| title_short | Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X |
| title_sort | helicobacter pylori infection maybe a risk factor for cardiac syndrome x |
| topic | Helicobacter pylori infection Cardiac syndrome X cytotoxin-associated gene A meta-analysis systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.823885/full |
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