Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients
Background: Schizophrenia is a disorder with considerable heterogeneity in course and outcomes, which is in part related to the patients' sex. Studies report a link between serum lipids, body mass index (BMI), and therapeutic response. However, the role of sex in these relationships is poorly u...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.723158/full |
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| author | Priyanthi B. Gjerde Priyanthi B. Gjerde Priyanthi B. Gjerde Carmen E. Simonsen Carmen E. Simonsen Trine V. Lagerberg Nils Eiel Steen Nils Eiel Steen Ole A. Andreassen Ole A. Andreassen Vidar M. Steen Vidar M. Steen Ingrid Melle Ingrid Melle |
| author_facet | Priyanthi B. Gjerde Priyanthi B. Gjerde Priyanthi B. Gjerde Carmen E. Simonsen Carmen E. Simonsen Trine V. Lagerberg Nils Eiel Steen Nils Eiel Steen Ole A. Andreassen Ole A. Andreassen Vidar M. Steen Vidar M. Steen Ingrid Melle Ingrid Melle |
| author_sort | Priyanthi B. Gjerde |
| collection | DOAJ |
| description | Background: Schizophrenia is a disorder with considerable heterogeneity in course and outcomes, which is in part related to the patients' sex. Studies report a link between serum lipids, body mass index (BMI), and therapeutic response. However, the role of sex in these relationships is poorly understood. In a cross-sectional sample of first-episode psychosis (FEP) patients, we investigated if the relationship between serum lipid levels (total cholesterol, HDL-C, LDL-C, and triglycerides), BMI, and symptoms differs between the sexes.Methods: We included 435 FEP patients (males: N = 283, 65%) from the ongoing Thematically Organized Psychosis (TOP) study. Data on clinical status, antipsychotics, lifestyle, serum lipid levels, and BMI were obtained. The Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS) were used to assess psychotic and depressive symptoms. General linear models were employed to examine the relationship between metabolic variables and symptomatology.Results: We observed a female-specific association between serum HDL-C levels and negative symptoms (B = −2.24, p = 0.03) and between triglycerides levels (B = 1.48, p = 0.04) and BMI (B = 0.27, p = 0.001) with depressive symptoms. When controlling for BMI, only the association between serum HDL-C levels and negative symptoms remained significant. Moreover, the HDL-C and BMI associations remained significant after controlling for demography, lifestyle, and illness-related factors.Conclusion: We found a relationship between metabolic factors and psychiatric symptoms in FEP patients that was sex-dependent. |
| first_indexed | 2024-12-16T07:32:25Z |
| format | Article |
| id | doaj.art-dfbb6ba41228445289f4eaf7538ff898 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-16T07:32:25Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-dfbb6ba41228445289f4eaf7538ff8982022-12-21T22:39:18ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-10-011210.3389/fpsyt.2021.723158723158Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis PatientsPriyanthi B. Gjerde0Priyanthi B. Gjerde1Priyanthi B. Gjerde2Carmen E. Simonsen3Carmen E. Simonsen4Trine V. Lagerberg5Nils Eiel Steen6Nils Eiel Steen7Ole A. Andreassen8Ole A. Andreassen9Vidar M. Steen10Vidar M. Steen11Ingrid Melle12Ingrid Melle13Norwegian Centre for Mental Disorders Research, Department of Clinical Science, University of Bergen, Bergen, NorwayDr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, NorwayResearch Unit for General Practice, NORCE Norwegian Research Centre, Bergen, NorwayNorwegian Centre for Mental Disorders Research, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayNorwegian Centre for Mental Disorders Research, Oslo University Hospital, Oslo, NorwayNorwegian Centre for Mental Disorders Research, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayNorwegian Centre for Mental Disorders Research, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayNorwegian Centre for Mental Disorders Research, Department of Clinical Science, University of Bergen, Bergen, NorwayDr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, NorwayNorwegian Centre for Mental Disorders Research, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayBackground: Schizophrenia is a disorder with considerable heterogeneity in course and outcomes, which is in part related to the patients' sex. Studies report a link between serum lipids, body mass index (BMI), and therapeutic response. However, the role of sex in these relationships is poorly understood. In a cross-sectional sample of first-episode psychosis (FEP) patients, we investigated if the relationship between serum lipid levels (total cholesterol, HDL-C, LDL-C, and triglycerides), BMI, and symptoms differs between the sexes.Methods: We included 435 FEP patients (males: N = 283, 65%) from the ongoing Thematically Organized Psychosis (TOP) study. Data on clinical status, antipsychotics, lifestyle, serum lipid levels, and BMI were obtained. The Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS) were used to assess psychotic and depressive symptoms. General linear models were employed to examine the relationship between metabolic variables and symptomatology.Results: We observed a female-specific association between serum HDL-C levels and negative symptoms (B = −2.24, p = 0.03) and between triglycerides levels (B = 1.48, p = 0.04) and BMI (B = 0.27, p = 0.001) with depressive symptoms. When controlling for BMI, only the association between serum HDL-C levels and negative symptoms remained significant. Moreover, the HDL-C and BMI associations remained significant after controlling for demography, lifestyle, and illness-related factors.Conclusion: We found a relationship between metabolic factors and psychiatric symptoms in FEP patients that was sex-dependent.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.723158/fullschizophreniapsychosisgenderserum lipidsBMIclinical outcome |
| spellingShingle | Priyanthi B. Gjerde Priyanthi B. Gjerde Priyanthi B. Gjerde Carmen E. Simonsen Carmen E. Simonsen Trine V. Lagerberg Nils Eiel Steen Nils Eiel Steen Ole A. Andreassen Ole A. Andreassen Vidar M. Steen Vidar M. Steen Ingrid Melle Ingrid Melle Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients Frontiers in Psychiatry schizophrenia psychosis gender serum lipids BMI clinical outcome |
| title | Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients |
| title_full | Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients |
| title_fullStr | Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients |
| title_full_unstemmed | Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients |
| title_short | Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients |
| title_sort | sex specific effect of serum lipids and body mass index on psychotic symptoms a cross sectional study of first episode psychosis patients |
| topic | schizophrenia psychosis gender serum lipids BMI clinical outcome |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.723158/full |
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