A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats.
<h4>Objectives</h4>In the arterial phase of gadoxetate disodium administration for dynamic MRI, transient severe motion (TSM) sometimes occurs, making image evaluation difficult. This study was to identify risk factors for TSM in a clinical study, and confirm them and investigate the cau...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0265588 |
| _version_ | 1828385984373325824 |
|---|---|
| author | Takumi Sugiura Kenichiro Okumura Motomitsu Sasaki Junichi Matsumoto Takahiro Ogi Norihide Yoneda Azusa Kitao Kazuto Kozaka Wataru Koda Satoshi Kobayashi Toshifumi Gabata |
| author_facet | Takumi Sugiura Kenichiro Okumura Motomitsu Sasaki Junichi Matsumoto Takahiro Ogi Norihide Yoneda Azusa Kitao Kazuto Kozaka Wataru Koda Satoshi Kobayashi Toshifumi Gabata |
| author_sort | Takumi Sugiura |
| collection | DOAJ |
| description | <h4>Objectives</h4>In the arterial phase of gadoxetate disodium administration for dynamic MRI, transient severe motion (TSM) sometimes occurs, making image evaluation difficult. This study was to identify risk factors for TSM in a clinical study, and confirm them and investigate the cause in an animal study.<h4>Methods</h4>A retrospective, single-center, observational study included patients who underwent dynamic MRI using gadoxetate disodium for the first time from April 2016 to September 2019 and free-breathing MRI was performed. Differences in clinical characteristics and laboratory tests between the presence and absence of TSM were examined. Animal experiments were conducted in 50 rats; gadoxetate disodium was injected into three sites (distal inferior vena cava (IVC), ascending aorta, and descending aorta) to identify the organ which triggers respiratory irregularities. Phosphate-buffered saline and gadopentetate dimeglumine were also injected into the distal IVC. In addition, to evaluate the effect of albumin, gadoxetate disodium was diluted with phosphate-buffered saline or 5% human serum albumin and injected into the ascending aorta. The time course of the respiratory rate was monitored and evaluated.<h4>Results</h4>20 of 51 (39.2%) patients showed TSM. On multivariable analysis, a low albumin level was an independent risk factor (P = .035). Gadoxetate disodium administration caused significant tachypnea compared to gadopentetate dimeglumine or PBS (an elevation of 16.6 vs 3.0 or 4.3 breaths/min; both P < .001) in rats. The starting time of tachypnea was earlier with injection into the ascending aorta than into the descending aorta (10.3 vs 17.9 sec; P < .001) and the distal IVC (vs 15.6 sec; P < .001). With dilution with albumin instead of phosphate-buffered saline, tachypnea was delayed and suppressed (9.9 vs 13.0 sec; P < .001, 24.1 vs 17.0 breaths/min; P = .031).<h4>Conclusions</h4>A low albumin level is a risk factor for TSM, which could be caused by the effect of gadoxetate disodium on the head and neck region. |
| first_indexed | 2024-12-10T05:29:19Z |
| format | Article |
| id | doaj.art-dfbbfaace88f47aca9f3751839637904 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T05:29:19Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dfbbfaace88f47aca9f37518396379042022-12-22T02:00:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173e026558810.1371/journal.pone.0265588A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats.Takumi SugiuraKenichiro OkumuraMotomitsu SasakiJunichi MatsumotoTakahiro OgiNorihide YonedaAzusa KitaoKazuto KozakaWataru KodaSatoshi KobayashiToshifumi Gabata<h4>Objectives</h4>In the arterial phase of gadoxetate disodium administration for dynamic MRI, transient severe motion (TSM) sometimes occurs, making image evaluation difficult. This study was to identify risk factors for TSM in a clinical study, and confirm them and investigate the cause in an animal study.<h4>Methods</h4>A retrospective, single-center, observational study included patients who underwent dynamic MRI using gadoxetate disodium for the first time from April 2016 to September 2019 and free-breathing MRI was performed. Differences in clinical characteristics and laboratory tests between the presence and absence of TSM were examined. Animal experiments were conducted in 50 rats; gadoxetate disodium was injected into three sites (distal inferior vena cava (IVC), ascending aorta, and descending aorta) to identify the organ which triggers respiratory irregularities. Phosphate-buffered saline and gadopentetate dimeglumine were also injected into the distal IVC. In addition, to evaluate the effect of albumin, gadoxetate disodium was diluted with phosphate-buffered saline or 5% human serum albumin and injected into the ascending aorta. The time course of the respiratory rate was monitored and evaluated.<h4>Results</h4>20 of 51 (39.2%) patients showed TSM. On multivariable analysis, a low albumin level was an independent risk factor (P = .035). Gadoxetate disodium administration caused significant tachypnea compared to gadopentetate dimeglumine or PBS (an elevation of 16.6 vs 3.0 or 4.3 breaths/min; both P < .001) in rats. The starting time of tachypnea was earlier with injection into the ascending aorta than into the descending aorta (10.3 vs 17.9 sec; P < .001) and the distal IVC (vs 15.6 sec; P < .001). With dilution with albumin instead of phosphate-buffered saline, tachypnea was delayed and suppressed (9.9 vs 13.0 sec; P < .001, 24.1 vs 17.0 breaths/min; P = .031).<h4>Conclusions</h4>A low albumin level is a risk factor for TSM, which could be caused by the effect of gadoxetate disodium on the head and neck region.https://doi.org/10.1371/journal.pone.0265588 |
| spellingShingle | Takumi Sugiura Kenichiro Okumura Motomitsu Sasaki Junichi Matsumoto Takahiro Ogi Norihide Yoneda Azusa Kitao Kazuto Kozaka Wataru Koda Satoshi Kobayashi Toshifumi Gabata A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats. PLoS ONE |
| title | A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats. |
| title_full | A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats. |
| title_fullStr | A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats. |
| title_full_unstemmed | A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats. |
| title_short | A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats. |
| title_sort | low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration a retrospective observational study with free breathing dynamic mri and an experimental study in rats |
| url | https://doi.org/10.1371/journal.pone.0265588 |
| work_keys_str_mv | AT takumisugiura alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT kenichirookumura alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT motomitsusasaki alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT junichimatsumoto alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT takahiroogi alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT norihideyoneda alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT azusakitao alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT kazutokozaka alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT watarukoda alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT satoshikobayashi alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT toshifumigabata alowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT takumisugiura lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT kenichirookumura lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT motomitsusasaki lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT junichimatsumoto lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT takahiroogi lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT norihideyoneda lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT azusakitao lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT kazutokozaka lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT watarukoda lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT satoshikobayashi lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats AT toshifumigabata lowalbuminlevelasariskfactorfortransientseveremotionartifactinducedbygadoxetatedisodiumadministrationaretrospectiveobservationalstudywithfreebreathingdynamicmriandanexperimentalstudyinrats |