Group therapy on in utero colonization: seeking common truths and a way forward
Abstract The human microbiome refers to the genetic composition of microorganisms in a particular location in the human body. Emerging evidence over the past many years suggests that the microbiome constitute drivers of human fate almost at par with our genome and epigenome. It is now well accepted...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Microbiome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40168-020-00968-w |
| _version_ | 1818595469038714880 |
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| author | Rachel B. Silverstein Indira U. Mysorekar |
| author_facet | Rachel B. Silverstein Indira U. Mysorekar |
| author_sort | Rachel B. Silverstein |
| collection | DOAJ |
| description | Abstract The human microbiome refers to the genetic composition of microorganisms in a particular location in the human body. Emerging evidence over the past many years suggests that the microbiome constitute drivers of human fate almost at par with our genome and epigenome. It is now well accepted after decades of disbelief that a broad understanding of human development, health, physiology, and disease requires understanding of the microbiome along with the genome and epigenome. We are learning daily of the interdependent relationships between microbiome/microbiota and immune responses, mood, cancer progression, response to therapies, aging, obesity, antibiotic usage, and overusage and much more. The next frontier in microbiome field is understanding when does this influence begin? Does the human microbiome initiate at the time of birth or are developing human fetuses already primed with microbes and their products in utero. In this commentary, we reflect on evidence gathered thus far on this question and identify the unknown common truths. We present a way forward to continue understanding our microbial colleagues and our interwoven fates. |
| first_indexed | 2024-12-16T11:16:30Z |
| format | Article |
| id | doaj.art-dfbdfcef32154bf7b04c5b4e016f9fff |
| institution | Directory Open Access Journal |
| issn | 2049-2618 |
| language | English |
| last_indexed | 2024-12-16T11:16:30Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbiome |
| spelling | doaj.art-dfbdfcef32154bf7b04c5b4e016f9fff2022-12-21T22:33:36ZengBMCMicrobiome2049-26182021-01-01911710.1186/s40168-020-00968-wGroup therapy on in utero colonization: seeking common truths and a way forwardRachel B. Silverstein0Indira U. Mysorekar1Department of Obstetrics and Gynecology, Washington University in St. Louis School of MedicineDepartment of Obstetrics and Gynecology, Washington University in St. Louis School of MedicineAbstract The human microbiome refers to the genetic composition of microorganisms in a particular location in the human body. Emerging evidence over the past many years suggests that the microbiome constitute drivers of human fate almost at par with our genome and epigenome. It is now well accepted after decades of disbelief that a broad understanding of human development, health, physiology, and disease requires understanding of the microbiome along with the genome and epigenome. We are learning daily of the interdependent relationships between microbiome/microbiota and immune responses, mood, cancer progression, response to therapies, aging, obesity, antibiotic usage, and overusage and much more. The next frontier in microbiome field is understanding when does this influence begin? Does the human microbiome initiate at the time of birth or are developing human fetuses already primed with microbes and their products in utero. In this commentary, we reflect on evidence gathered thus far on this question and identify the unknown common truths. We present a way forward to continue understanding our microbial colleagues and our interwoven fates.https://doi.org/10.1186/s40168-020-00968-wDeciduaPregnancyPlacentaExtravillous trophoblastsMicrobiomeLow biomass microbial communities |
| spellingShingle | Rachel B. Silverstein Indira U. Mysorekar Group therapy on in utero colonization: seeking common truths and a way forward Microbiome Decidua Pregnancy Placenta Extravillous trophoblasts Microbiome Low biomass microbial communities |
| title | Group therapy on in utero colonization: seeking common truths and a way forward |
| title_full | Group therapy on in utero colonization: seeking common truths and a way forward |
| title_fullStr | Group therapy on in utero colonization: seeking common truths and a way forward |
| title_full_unstemmed | Group therapy on in utero colonization: seeking common truths and a way forward |
| title_short | Group therapy on in utero colonization: seeking common truths and a way forward |
| title_sort | group therapy on in utero colonization seeking common truths and a way forward |
| topic | Decidua Pregnancy Placenta Extravillous trophoblasts Microbiome Low biomass microbial communities |
| url | https://doi.org/10.1186/s40168-020-00968-w |
| work_keys_str_mv | AT rachelbsilverstein grouptherapyoninuterocolonizationseekingcommontruthsandawayforward AT indiraumysorekar grouptherapyoninuterocolonizationseekingcommontruthsandawayforward |