Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis
Abstract Helminth-derived proteins have immunomodulatory properties, influencing the host’s immune response as an adaptive strategy for helminth survival. Helminth-derived proteins modulate the immune response by inducing anti-inflammatory cytokines, promoting regulatory T-cell development, and ulti...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-024-00614-2 |
| _version_ | 1827074822828457984 |
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| author | Maimonah Alghanmi Faisal Minshawi Tarfa A. Altorki Ayat Zawawi Isra Alsaady Abdallah Y Naser Hassan Alwafi Soa’ad M. Alsulami Ala A. Azhari Anwar M Hashem Rowa Alhabbab |
| author_facet | Maimonah Alghanmi Faisal Minshawi Tarfa A. Altorki Ayat Zawawi Isra Alsaady Abdallah Y Naser Hassan Alwafi Soa’ad M. Alsulami Ala A. Azhari Anwar M Hashem Rowa Alhabbab |
| author_sort | Maimonah Alghanmi |
| collection | DOAJ |
| description | Abstract Helminth-derived proteins have immunomodulatory properties, influencing the host’s immune response as an adaptive strategy for helminth survival. Helminth-derived proteins modulate the immune response by inducing anti-inflammatory cytokines, promoting regulatory T-cell development, and ultimately favouring a Th2-biased immune response. This systematic review focused on helminth-derived proteins and explored their impact on reducing inflammatory responses in mouse models of colitis. A systematic search across Medline, EMBASE, Web of Science, and Cochrane Library identified fourteen relevant studies. These studies reported immunomodulatory changes, including increased production of anti-inflammatory cells and cytokines. In mouse models of colitis treated with on helminth-derived proteins, significant improvements in pathological parameters such as body weight, colon length, and microscopic inflammatory scores were observed compared to control groups. Moreover, helminth-derived proteins can enhance the function of Tregs and alleviate the severity of inflammatory conditions. The findings underscore the pivotal role of helminth-derived proteins in immunomodulation, specifically in the axis of cytokine secretion and immune cell polarization. The findings offer new opportunities for treating chronic inflammatory conditions such Crohn’s disease. |
| first_indexed | 2024-04-24T07:17:54Z |
| format | Article |
| id | doaj.art-dfc1143c059e4f4aa94b22cb67ab4044 |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2025-03-20T01:32:12Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-dfc1143c059e4f4aa94b22cb67ab40442024-10-06T11:17:35ZengBMCBMC Immunology1471-21722024-04-0125111010.1186/s12865-024-00614-2Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitisMaimonah Alghanmi0Faisal Minshawi1Tarfa A. Altorki2Ayat Zawawi3Isra Alsaady4Abdallah Y Naser5Hassan Alwafi6Soa’ad M. Alsulami7Ala A. Azhari8Anwar M Hashem9Rowa Alhabbab10Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz UniversityDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura UniversityDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz UniversityDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz UniversityDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz UniversityDepartment of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra UniversityFaculty of Medicine, Umm Al-Qura UniversityDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz UniversityVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz UniversityVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz UniversityDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz UniversityAbstract Helminth-derived proteins have immunomodulatory properties, influencing the host’s immune response as an adaptive strategy for helminth survival. Helminth-derived proteins modulate the immune response by inducing anti-inflammatory cytokines, promoting regulatory T-cell development, and ultimately favouring a Th2-biased immune response. This systematic review focused on helminth-derived proteins and explored their impact on reducing inflammatory responses in mouse models of colitis. A systematic search across Medline, EMBASE, Web of Science, and Cochrane Library identified fourteen relevant studies. These studies reported immunomodulatory changes, including increased production of anti-inflammatory cells and cytokines. In mouse models of colitis treated with on helminth-derived proteins, significant improvements in pathological parameters such as body weight, colon length, and microscopic inflammatory scores were observed compared to control groups. Moreover, helminth-derived proteins can enhance the function of Tregs and alleviate the severity of inflammatory conditions. The findings underscore the pivotal role of helminth-derived proteins in immunomodulation, specifically in the axis of cytokine secretion and immune cell polarization. The findings offer new opportunities for treating chronic inflammatory conditions such Crohn’s disease.https://doi.org/10.1186/s12865-024-00614-2HelminthsImmunoregulationInflammatory bowel diseaseColitisUlcerative colitisCrohn’s disease |
| spellingShingle | Maimonah Alghanmi Faisal Minshawi Tarfa A. Altorki Ayat Zawawi Isra Alsaady Abdallah Y Naser Hassan Alwafi Soa’ad M. Alsulami Ala A. Azhari Anwar M Hashem Rowa Alhabbab Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis BMC Immunology Helminths Immunoregulation Inflammatory bowel disease Colitis Ulcerative colitis Crohn’s disease |
| title | Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis |
| title_full | Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis |
| title_fullStr | Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis |
| title_full_unstemmed | Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis |
| title_short | Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis |
| title_sort | helminth derived proteins as immune system regulators a systematic review of their promise in alleviating colitis |
| topic | Helminths Immunoregulation Inflammatory bowel disease Colitis Ulcerative colitis Crohn’s disease |
| url | https://doi.org/10.1186/s12865-024-00614-2 |
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