The Role of RNA Modification in HIV-1 Infection
RNA plays an important role in biology, and more than 170 RNA modifications have been identified so far. Post-transcriptional modification of RNA in cells plays a crucial role in the regulation of its stability, transport, processing, and gene expression. So far, the research on RNA modification and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/7571 |
| _version_ | 1797446657701314560 |
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| author | Shuqi Wang Huanxiang Li Zhengxing Lian Shoulong Deng |
| author_facet | Shuqi Wang Huanxiang Li Zhengxing Lian Shoulong Deng |
| author_sort | Shuqi Wang |
| collection | DOAJ |
| description | RNA plays an important role in biology, and more than 170 RNA modifications have been identified so far. Post-transcriptional modification of RNA in cells plays a crucial role in the regulation of its stability, transport, processing, and gene expression. So far, the research on RNA modification and the exact role of its enzymes is becoming more and more comprehensive. Human immunodeficiency virus 1 (HIV-1) is an RNA virus and the causative agent of acquired immunodeficiency syndrome (AIDS), which is one of the most devastating viral pandemics in history. More and more studies have shown that HIV has RNA modifications and regulation of its gene expression during infection and replication. This review focuses on several RNA modifications and their regulatory roles as well as the roles that different RNA modifications play during HIV-1 infection, in order to find new approaches for the development of anti-HIV-1 therapeutics. |
| first_indexed | 2024-03-09T13:43:44Z |
| format | Article |
| id | doaj.art-dfc19544c02b47d3a0959f2f135a36dd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:43:44Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dfc19544c02b47d3a0959f2f135a36dd2023-11-30T21:03:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314757110.3390/ijms23147571The Role of RNA Modification in HIV-1 InfectionShuqi Wang0Huanxiang Li1Zhengxing Lian2Shoulong Deng3Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaNHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, ChinaRNA plays an important role in biology, and more than 170 RNA modifications have been identified so far. Post-transcriptional modification of RNA in cells plays a crucial role in the regulation of its stability, transport, processing, and gene expression. So far, the research on RNA modification and the exact role of its enzymes is becoming more and more comprehensive. Human immunodeficiency virus 1 (HIV-1) is an RNA virus and the causative agent of acquired immunodeficiency syndrome (AIDS), which is one of the most devastating viral pandemics in history. More and more studies have shown that HIV has RNA modifications and regulation of its gene expression during infection and replication. This review focuses on several RNA modifications and their regulatory roles as well as the roles that different RNA modifications play during HIV-1 infection, in order to find new approaches for the development of anti-HIV-1 therapeutics.https://www.mdpi.com/1422-0067/23/14/7571RNA modificationHIV-1 infectionRNA methylation modificationRNA viruspost-transcriptional modification |
| spellingShingle | Shuqi Wang Huanxiang Li Zhengxing Lian Shoulong Deng The Role of RNA Modification in HIV-1 Infection International Journal of Molecular Sciences RNA modification HIV-1 infection RNA methylation modification RNA virus post-transcriptional modification |
| title | The Role of RNA Modification in HIV-1 Infection |
| title_full | The Role of RNA Modification in HIV-1 Infection |
| title_fullStr | The Role of RNA Modification in HIV-1 Infection |
| title_full_unstemmed | The Role of RNA Modification in HIV-1 Infection |
| title_short | The Role of RNA Modification in HIV-1 Infection |
| title_sort | role of rna modification in hiv 1 infection |
| topic | RNA modification HIV-1 infection RNA methylation modification RNA virus post-transcriptional modification |
| url | https://www.mdpi.com/1422-0067/23/14/7571 |
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