Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/20/15254 |
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| author | Carlos Fernández-Pereira Maria Aránzazu Penedo Tania Rivera-Baltanás Tania Pérez-Márquez Marta Alves-Villar Rafael Fernández-Martínez César Veiga Ángel Salgado-Barreira José María Prieto-González Saida Ortolano José Manuel Olivares Roberto Carlos Agís-Balboa |
| author_facet | Carlos Fernández-Pereira Maria Aránzazu Penedo Tania Rivera-Baltanás Tania Pérez-Márquez Marta Alves-Villar Rafael Fernández-Martínez César Veiga Ángel Salgado-Barreira José María Prieto-González Saida Ortolano José Manuel Olivares Roberto Carlos Agís-Balboa |
| author_sort | Carlos Fernández-Pereira |
| collection | DOAJ |
| description | The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression. |
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| format | Article |
| id | doaj.art-dfc1d3a1f98a4937baf3bdaa86785197 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:12:14Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dfc1d3a1f98a4937baf3bdaa867851972023-11-19T16:43:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124201525410.3390/ijms242015254Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive DisorderCarlos Fernández-Pereira0Maria Aránzazu Penedo1Tania Rivera-Baltanás2Tania Pérez-Márquez3Marta Alves-Villar4Rafael Fernández-Martínez5César Veiga6Ángel Salgado-Barreira7José María Prieto-González8Saida Ortolano9José Manuel Olivares10Roberto Carlos Agís-Balboa11Translational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, SpainTranslational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, SpainTranslational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, SpainRare Disease and Pediatric Medicine Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, SpainRare Disease and Pediatric Medicine Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, SpainTranslational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, SpainCardiovascular Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), 36213 Vigo, SpainDepartment of Preventive Medicine and Public Health, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, 15706 Santiago de Compostela, SpainNeuro Epigenetics Lab, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, 15706 Santiago de Compostela, SpainRare Disease and Pediatric Medicine Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, SpainTranslational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, SpainNeuro Epigenetics Lab, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, 15706 Santiago de Compostela, SpainThe Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression.https://www.mdpi.com/1422-0067/24/20/15254Insulin-like growth factor 2 (IGF-2)Insulin-like growth factor binding protein 1 (IGFBP-1)Insulin-like growth factor binding protein 3 (IGFBP-3)Insulin-like growth factor binding protein 5 (IGFBP-5)Insulin-like growth factor binding protein 7 (IGFBP-7)depression |
| spellingShingle | Carlos Fernández-Pereira Maria Aránzazu Penedo Tania Rivera-Baltanás Tania Pérez-Márquez Marta Alves-Villar Rafael Fernández-Martínez César Veiga Ángel Salgado-Barreira José María Prieto-González Saida Ortolano José Manuel Olivares Roberto Carlos Agís-Balboa Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder International Journal of Molecular Sciences Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression |
| title | Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder |
| title_full | Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder |
| title_fullStr | Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder |
| title_full_unstemmed | Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder |
| title_short | Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder |
| title_sort | protein plasma levels of the igf signalling system are altered in major depressive disorder |
| topic | Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression |
| url | https://www.mdpi.com/1422-0067/24/20/15254 |
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