Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
BackgroundCOVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron vari...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.975533/full |
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| author | Yudi Xie Yudi Xie Lei Liu Jue Wang Jue Wang Yaqiong Zheng Chen Luo Chen Luo Wenxu Ni Zhihang He Zhihang He Xin Zhao Xin Zhao Yan Liu Yingyu He Shangen Zheng Ling Li Ling Li Ling Li Zhong Liu Zhong Liu Zhong Liu |
| author_facet | Yudi Xie Yudi Xie Lei Liu Jue Wang Jue Wang Yaqiong Zheng Chen Luo Chen Luo Wenxu Ni Zhihang He Zhihang He Xin Zhao Xin Zhao Yan Liu Yingyu He Shangen Zheng Ling Li Ling Li Ling Li Zhong Liu Zhong Liu Zhong Liu |
| author_sort | Yudi Xie |
| collection | DOAJ |
| description | BackgroundCOVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain.MethodsThe pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group.ResultsIn the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps<0.001), but the difference between Delta and Omicron variants were not significant (p>0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p<0.01).ConclusionsAmong the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of vaccine could significantly raise the average neutralization of Omicron in convalescent individuals. |
| first_indexed | 2024-04-12T04:21:42Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T04:21:42Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dfc21ab48ad64779810a750cad251e4c2022-12-22T03:48:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.975533975533Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variantsYudi Xie0Yudi Xie1Lei Liu2Jue Wang3Jue Wang4Yaqiong Zheng5Chen Luo6Chen Luo7Wenxu Ni8Zhihang He9Zhihang He10Xin Zhao11Xin Zhao12Yan Liu13Yingyu He14Shangen Zheng15Ling Li16Ling Li17Ling Li18Zhong Liu19Zhong Liu20Zhong Liu21Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, ChinaKey Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, ChinaGeneral Hospital of Central Theater Command of the PLA, Wuhan, ChinaInstitute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, ChinaKey Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, ChinaGeneral Hospital of Central Theater Command of the PLA, Wuhan, ChinaInstitute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, ChinaKey Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, ChinaGeneral Hospital of Central Theater Command of the PLA, Wuhan, ChinaInstitute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, ChinaKey Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, ChinaInstitute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, ChinaKey Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, ChinaGeneral Hospital of Central Theater Command of the PLA, Wuhan, ChinaGeneral Hospital of Central Theater Command of the PLA, Wuhan, ChinaGeneral Hospital of Central Theater Command of the PLA, Wuhan, ChinaInstitute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, ChinaKey Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, ChinaCollege of Public Hygiene of Anhui Medical University, Hefei, ChinaInstitute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, ChinaKey Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, ChinaCollege of Public Hygiene of Anhui Medical University, Hefei, ChinaBackgroundCOVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain.MethodsThe pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group.ResultsIn the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps<0.001), but the difference between Delta and Omicron variants were not significant (p>0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p<0.01).ConclusionsAmong the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of vaccine could significantly raise the average neutralization of Omicron in convalescent individuals.https://www.frontiersin.org/articles/10.3389/fimmu.2022.975533/fullSARS-CoV-2convalescentvaccineneutralizationdeltaomicron |
| spellingShingle | Yudi Xie Yudi Xie Lei Liu Jue Wang Jue Wang Yaqiong Zheng Chen Luo Chen Luo Wenxu Ni Zhihang He Zhihang He Xin Zhao Xin Zhao Yan Liu Yingyu He Shangen Zheng Ling Li Ling Li Ling Li Zhong Liu Zhong Liu Zhong Liu Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants Frontiers in Immunology SARS-CoV-2 convalescent vaccine neutralization delta omicron |
| title | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
| title_full | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
| title_fullStr | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
| title_full_unstemmed | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
| title_short | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
| title_sort | neutralization effect of plasma from vaccinated covid 19 convalescents on sars cov 2 omicron variants |
| topic | SARS-CoV-2 convalescent vaccine neutralization delta omicron |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.975533/full |
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