Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma
Background: The factor behind the activation of the remnant odontogenic tissues and development of odontogenic cysts and tumors is poorly understood.This study aimed to investigate the presence of human cytomegalovirus (HCMV) in dentigerous cyst (DC), odontogenic keratocyst (OKC), and ameloblastoma...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20002297.2021.1874699 |
| _version_ | 1828885207237787648 |
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| author | Mohammed Amjed Alsaegh Sudhir Rama Varma Alaa Muayad Altaie Shengrong Zhu |
| author_facet | Mohammed Amjed Alsaegh Sudhir Rama Varma Alaa Muayad Altaie Shengrong Zhu |
| author_sort | Mohammed Amjed Alsaegh |
| collection | DOAJ |
| description | Background: The factor behind the activation of the remnant odontogenic tissues and development of odontogenic cysts and tumors is poorly understood.This study aimed to investigate the presence of human cytomegalovirus (HCMV) in dentigerous cyst (DC), odontogenic keratocyst (OKC), and ameloblastoma (AB). Methods: The study included 41 samples, which distributed into DC (n=13), OKC (n=12), and AB (n=16). Conventional PCR assay and IHC analysis were used to detect the HCMV-DNA and HCMV glycoprotein B (HCMV-gB) respectively. Results: HCMV-DNA was detected in 10 samples (62.5%) of AB, four samples (30.8%) of DC, and three samples (25 %) of OKC respectively (χ2 test = 1.195, p= 0.247). Meanwhile, HCMV-gB was found in 12 (75%) of AB, in 2 (15.4%) of DC, and absent in OKC (0.0%) (χ2 test = 4.122, p= 0.042). Conclusions: The high prevalence of HCMV inside the odontogenic epithelium of AB could indicate a possible role of the virus in the oncogenesis and/or oncomodulation of the AB. Additionally, we recommend the IHC for the detection of HCMV in the odontogenic tumors like AB. |
| first_indexed | 2024-12-13T11:22:21Z |
| format | Article |
| id | doaj.art-dfc323cd2d2449dca6ece2379ea8e2dd |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-13T11:22:21Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-dfc323cd2d2449dca6ece2379ea8e2dd2022-12-21T23:48:25ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972021-01-0113110.1080/20002297.2021.18746991874699Human cytomegalovirus is present in the odontogenic epithelium of ameloblastomaMohammed Amjed Alsaegh0Sudhir Rama Varma1Alaa Muayad Altaie2Shengrong Zhu3College of Dental Medicine, University of SharjahCollege of Dentistry, Ajman UniversitySharjah UniversityTongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyBackground: The factor behind the activation of the remnant odontogenic tissues and development of odontogenic cysts and tumors is poorly understood.This study aimed to investigate the presence of human cytomegalovirus (HCMV) in dentigerous cyst (DC), odontogenic keratocyst (OKC), and ameloblastoma (AB). Methods: The study included 41 samples, which distributed into DC (n=13), OKC (n=12), and AB (n=16). Conventional PCR assay and IHC analysis were used to detect the HCMV-DNA and HCMV glycoprotein B (HCMV-gB) respectively. Results: HCMV-DNA was detected in 10 samples (62.5%) of AB, four samples (30.8%) of DC, and three samples (25 %) of OKC respectively (χ2 test = 1.195, p= 0.247). Meanwhile, HCMV-gB was found in 12 (75%) of AB, in 2 (15.4%) of DC, and absent in OKC (0.0%) (χ2 test = 4.122, p= 0.042). Conclusions: The high prevalence of HCMV inside the odontogenic epithelium of AB could indicate a possible role of the virus in the oncogenesis and/or oncomodulation of the AB. Additionally, we recommend the IHC for the detection of HCMV in the odontogenic tumors like AB.http://dx.doi.org/10.1080/20002297.2021.1874699hcmvcytomegalovirusodontogenic tumorameloblastomadentigerous cystkeratocystodontogenic |
| spellingShingle | Mohammed Amjed Alsaegh Sudhir Rama Varma Alaa Muayad Altaie Shengrong Zhu Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma Journal of Oral Microbiology hcmv cytomegalovirus odontogenic tumor ameloblastoma dentigerous cyst keratocyst odontogenic |
| title | Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma |
| title_full | Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma |
| title_fullStr | Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma |
| title_full_unstemmed | Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma |
| title_short | Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma |
| title_sort | human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma |
| topic | hcmv cytomegalovirus odontogenic tumor ameloblastoma dentigerous cyst keratocyst odontogenic |
| url | http://dx.doi.org/10.1080/20002297.2021.1874699 |
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