Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis
Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-prov...
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MDPI AG
2020-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/7/2135 |
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| author | Raquel Esteras Jonathan G. Fox Colin C. Geddes Bruce Mackinnon Alberto Ortiz Juan Antonio Moreno |
| author_facet | Raquel Esteras Jonathan G. Fox Colin C. Geddes Bruce Mackinnon Alberto Ortiz Juan Antonio Moreno |
| author_sort | Raquel Esteras |
| collection | DOAJ |
| description | Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-proven ATIN was conducted. Results: Haematuria was present in 66 (60%) ATIN patients. A higher percentage of ATIN patients with haematuria had proteinuria than patients without haematuria (89.4% vs. 59.1%, <i>p</i> = 0.001) with significantly higher levels of proteinuria (median (interquartile range) protein:creatinine ratio 902.70 (513–1492) vs. 341.00 (177–734) mg/g, <i>p</i> <0.001). Moreover, those patients with more haematuria intensity had a higher urinary protein:creatinine ratio (1352.65 (665–2292) vs. 849.60 (562–1155) mg/g, <i>p</i> = 0.02). Those patients with higher proteinuria were more likely to need renal replacement therapy (22.7 vs. 0%, <i>p</i> = 0.03) and to suffer relapse (4 vs. 0%, <i>p</i> = 0.03). At the end of follow up, haematuric ATIN patients had higher serum creatinine levels (3.19 ± 2.91 vs. 1.91 ± 1.17 mg/dL, <i>p</i> = 0.007), and a trend towards a higher need for acute dialysis (7 vs. 1%, <i>p</i> = 0.09) and renal replacement therapy (12.1 vs. 2.3%, <i>p</i> = 0.12). Haematuria is common in ATIN and it is associated with worse renal function outcomes. |
| first_indexed | 2024-03-10T18:38:59Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:38:59Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-dfc3cd0e11ba4e7490175b5d3d64b4bf2023-11-20T06:01:42ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0197213510.3390/jcm9072135Hematuria Is Associated with More Severe Acute Tubulointerstitial NephritisRaquel Esteras0Jonathan G. Fox1Colin C. Geddes2Bruce Mackinnon3Alberto Ortiz4Juan Antonio Moreno5Renal Laboratory, Health Research Institute-Fundación Jimenez Diaz (IIS-FJD), Autónoma University of Madrid (UAM), 28040 Madrid, SpainGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow G51 4TF, UKGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow G51 4TF, UKDepartment of Nephrology and Transplantation, John Hunter Hospital, Newcastle, NSW 2310, AustraliaRenal Laboratory, Health Research Institute-Fundación Jimenez Diaz (IIS-FJD), Autónoma University of Madrid (UAM), 28040 Madrid, SpainDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, 14041 Cordoba, SpainAcute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-proven ATIN was conducted. Results: Haematuria was present in 66 (60%) ATIN patients. A higher percentage of ATIN patients with haematuria had proteinuria than patients without haematuria (89.4% vs. 59.1%, <i>p</i> = 0.001) with significantly higher levels of proteinuria (median (interquartile range) protein:creatinine ratio 902.70 (513–1492) vs. 341.00 (177–734) mg/g, <i>p</i> <0.001). Moreover, those patients with more haematuria intensity had a higher urinary protein:creatinine ratio (1352.65 (665–2292) vs. 849.60 (562–1155) mg/g, <i>p</i> = 0.02). Those patients with higher proteinuria were more likely to need renal replacement therapy (22.7 vs. 0%, <i>p</i> = 0.03) and to suffer relapse (4 vs. 0%, <i>p</i> = 0.03). At the end of follow up, haematuric ATIN patients had higher serum creatinine levels (3.19 ± 2.91 vs. 1.91 ± 1.17 mg/dL, <i>p</i> = 0.007), and a trend towards a higher need for acute dialysis (7 vs. 1%, <i>p</i> = 0.09) and renal replacement therapy (12.1 vs. 2.3%, <i>p</i> = 0.12). Haematuria is common in ATIN and it is associated with worse renal function outcomes.https://www.mdpi.com/2077-0383/9/7/2135acute kidney injuryacute tubulointerstitial nephritishaematuriakidney biopsyoutcomesproteinuria |
| spellingShingle | Raquel Esteras Jonathan G. Fox Colin C. Geddes Bruce Mackinnon Alberto Ortiz Juan Antonio Moreno Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis Journal of Clinical Medicine acute kidney injury acute tubulointerstitial nephritis haematuria kidney biopsy outcomes proteinuria |
| title | Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis |
| title_full | Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis |
| title_fullStr | Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis |
| title_full_unstemmed | Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis |
| title_short | Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis |
| title_sort | hematuria is associated with more severe acute tubulointerstitial nephritis |
| topic | acute kidney injury acute tubulointerstitial nephritis haematuria kidney biopsy outcomes proteinuria |
| url | https://www.mdpi.com/2077-0383/9/7/2135 |
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