Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study
<i>Background and Objectives</i>: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. <i>Materials and Methods</i>: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in length) was in...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/1996-1944/14/22/7076 |
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| author | Christian Flörke Anne-Katrin Eisenbeiß Ulla Metz Aydin Gülses Yahya Acil Jörg Wiltfang Hendrik Naujokat |
| author_facet | Christian Flörke Anne-Katrin Eisenbeiß Ulla Metz Aydin Gülses Yahya Acil Jörg Wiltfang Hendrik Naujokat |
| author_sort | Christian Flörke |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. <i>Materials and Methods</i>: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in length) was inserted into frontal bone (n: 12) and the basis of the corpus mandible (n: 24). Eighteen implants were contaminated via inoculation of <i>Enterococcus faecalis</i>. Six weeks after implant insertion, bone-to-implant contact (BIC) ratio, interthread bone density (ITBD), and peri-implant bone density (PIBD) were examined. In addition to that, new bone formation was assessed via fluorescence microscopy, histomorphometry, and light microscopical examinations. <i>Results</i>: Compared to the sterile implants, the contaminated implants showed significantly reduced BIC (<i>p</i> < 0.001), ITBD (<i>p</i> < 0.001), and PBD (<i>p</i> < 0.001) values. Around the sterile implants, the green and red fluorophores were overlapping and surrounding the implant without gaps, indicating healthy bone growth on the implant surface, whereas contaminated implants were surrounded by connective tissue. <i>Conclusions</i>: The current experimental model could be a feasible option to realize a significant alteration of dental-implant osseointegration and examine novel surface decontamination techniques without impairing local and systemic inflammatory complications. |
| first_indexed | 2024-03-10T05:19:14Z |
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| id | doaj.art-dfc5606d0ab5480fb1c79fbd8b6b8657 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T05:19:14Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
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| series | Materials |
| spelling | doaj.art-dfc5606d0ab5480fb1c79fbd8b6b86572023-11-23T00:13:20ZengMDPI AGMaterials1996-19442021-11-011422707610.3390/ma14227076Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility StudyChristian Flörke0Anne-Katrin Eisenbeiß1Ulla Metz2Aydin Gülses3Yahya Acil4Jörg Wiltfang5Hendrik Naujokat6Department of Oral and Maxillofacial Surgery, UKSH, Christian-Albrechts-University, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, UKSH, Christian-Albrechts-University, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, UKSH, Christian-Albrechts-University, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, UKSH, Christian-Albrechts-University, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, UKSH, Christian-Albrechts-University, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, UKSH, Christian-Albrechts-University, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, UKSH, Christian-Albrechts-University, 24105 Kiel, Germany<i>Background and Objectives</i>: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. <i>Materials and Methods</i>: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in length) was inserted into frontal bone (n: 12) and the basis of the corpus mandible (n: 24). Eighteen implants were contaminated via inoculation of <i>Enterococcus faecalis</i>. Six weeks after implant insertion, bone-to-implant contact (BIC) ratio, interthread bone density (ITBD), and peri-implant bone density (PIBD) were examined. In addition to that, new bone formation was assessed via fluorescence microscopy, histomorphometry, and light microscopical examinations. <i>Results</i>: Compared to the sterile implants, the contaminated implants showed significantly reduced BIC (<i>p</i> < 0.001), ITBD (<i>p</i> < 0.001), and PBD (<i>p</i> < 0.001) values. Around the sterile implants, the green and red fluorophores were overlapping and surrounding the implant without gaps, indicating healthy bone growth on the implant surface, whereas contaminated implants were surrounded by connective tissue. <i>Conclusions</i>: The current experimental model could be a feasible option to realize a significant alteration of dental-implant osseointegration and examine novel surface decontamination techniques without impairing local and systemic inflammatory complications.https://www.mdpi.com/1996-1944/14/22/7076dental<i>Enterococcus faecalis</i>implantosseointegrationperi-implantitis |
| spellingShingle | Christian Flörke Anne-Katrin Eisenbeiß Ulla Metz Aydin Gülses Yahya Acil Jörg Wiltfang Hendrik Naujokat Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study Materials dental <i>Enterococcus faecalis</i> implant osseointegration peri-implantitis |
| title | Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study |
| title_full | Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study |
| title_fullStr | Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study |
| title_full_unstemmed | Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study |
| title_short | Introducing a Novel Experimental Model for Osseo-Disintegration of Titanium Dental Implants Induced by Monobacterial Contamination: An In-Vivo Feasibility Study |
| title_sort | introducing a novel experimental model for osseo disintegration of titanium dental implants induced by monobacterial contamination an in vivo feasibility study |
| topic | dental <i>Enterococcus faecalis</i> implant osseointegration peri-implantitis |
| url | https://www.mdpi.com/1996-1944/14/22/7076 |
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