Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future

Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future

Reactive oxygen species play a significant role in the pathogenesis of various ocular neurodegenerative diseases especially glaucoma, age-related macular degeneration (AMD), and ocular ischemic stroke. Increased oxidative stress and the accumulation of ROS have been implicated in the progression of...

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Manylion Llyfryddiaeth
Prif Awduron:	Charles E. Amankwa, Bindu Kodati, Nina Donkor, Suchismita Acharya
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	MDPI AG 2023-11-01
Cyfres:	Biomedicines
Pynciau:	nitric oxide reactive oxygen species glaucoma oxidative stress TEMPOL derivatives neuroprotection
Mynediad Ar-lein:	https://www.mdpi.com/2227-9059/11/11/2959

Eitemau Tebyg

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Tempol Supplementation Restores Diaphragm Force and Metabolic Enzyme Activities in mdx Mice
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Cyhoeddwyd: (2017-12-01)

Tempol Alters Antioxidant Enzyme Function, Modulates Multiple Genes Expression, and Ameliorates Hepatic and Renal Impairment in Carbon Tetrachloride (CCl<sub>4</sub>)-Intoxicated Rats
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Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained-mdx Mice
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Efficacy of the Radical Scavenger, Tempol, to Reduce Inflammation and Oxidative Stress in a Murine Model of Atopic Dermatitis
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Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker
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Cyhoeddwyd: (2024-02-01)

Systemic Administration of Tempol, a Superoxide Dismutase Mimetic, Augments Upper Airway Muscle Activity in Obese Zucker Rats
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Cyhoeddwyd: (2022-02-01)

Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect of TEMPOL in Zebrafish Model
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Cyhoeddwyd: (2021-01-01)

The effect of TEMPOL pretreatment on postoperative cognitive function, inflammatory response, and oxidative stress in aged rats under sevoflurane anesthesia
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Beneficial Effect of Tempol, a Membrane-Permeable Radical Scavenger, on Inflammation and Osteoarthritis in In Vitro Models
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Cyhoeddwyd: (2021-02-01)

Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl
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Tempol Inhibits the Growth of Lung Cancer and Normal Cells through Apoptosis Accompanied by Increased O<sub>2</sub><sup>•−</sup> Levels and Glutathione Depletion
gan: Woo Hyun Park
Cyhoeddwyd: (2022-10-01)

Tempol Reverses the Negative Effects of Morphine on Arterial Blood-Gas Chemistry and Tissue Oxygen Saturation in Freely-Moving Rats
gan: Santhosh M. Baby, et al.
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Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
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Cyhoeddwyd: (2019-11-01)

Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress
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Cyhoeddwyd: (2018-12-01)

In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue
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Cyhoeddwyd: (2021-11-01)

Neuroprotection of Rodent and Human Retinal Ganglion Cells In Vitro/Ex Vivo by the Hybrid Small Molecule SA-2
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Cyhoeddwyd: (2022-11-01)

Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway
gan: Gensheng Zhang, et al.
Cyhoeddwyd: (2016-02-01)

Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma
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Cyhoeddwyd: (2021-04-01)

Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
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Cyhoeddwyd: (2016-09-01)

Efficient Scavenging of TEMPOL Radical by Ascorbic Acid in Solution and Related Prolongation of <sup>13</sup>C and <sup>1</sup>H Nuclear Spin Relaxation Times of the Solute
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Comparative study between apocynin and protocatechuic acid regarding antioxidant capacity and vascular effects
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Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension
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Cyhoeddwyd: (2016-08-01)

Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3β Signaling Cascades and Afferent Arteriolar Activity
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Cyhoeddwyd: (2018-05-01)

Protective role of 3-oxypyridine derivatives in rats’ steroid-induced osteoporosis associated with reduced oxidative stress and recovery of nitric oxide formation
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Cyhoeddwyd: (2023-05-01)

Improving Endogenous Nitric Oxide Enhances Cadmium Tolerance in Rice through Modulation of Cadmium Accumulation and Antioxidant Capacity
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Cyhoeddwyd: (2023-07-01)

Nitric oxide levels in the aqueous humor vary in different ocular hypertension experimental models
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Cyhoeddwyd: (2014-12-01)

Tempol improves optic nerve histopathology and ultrastructures in cisplatin-induced optic neuropathy in rats by targeting oxidative stress—Endoplasmic reticulum stress—Autophagy signaling pathways
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Cyhoeddwyd: (2023-10-01)

Tempol Alters Urinary Extracellular Vesicle Lipid Content and Release While Reducing Blood Pressure during the Development of Salt-Sensitive Hypertension
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Cyhoeddwyd: (2021-12-01)

Nitric Oxide Interaction with the Eye
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Cyhoeddwyd: (2021-06-01)

Rapid Eye Movement sleep deprivation of rat generates ROS in the hepatocytes and makes them more susceptible to oxidative stress
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Nitric oxide ameliorates stress responses in plants
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Cyhoeddwyd: (2011-03-01)

Nitric oxide, antioxidants and prooxidants in plant defence responses
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Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease
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