Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future

Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future

Reactive oxygen species play a significant role in the pathogenesis of various ocular neurodegenerative diseases especially glaucoma, age-related macular degeneration (AMD), and ocular ischemic stroke. Increased oxidative stress and the accumulation of ROS have been implicated in the progression of...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Charles E. Amankwa, Bindu Kodati, Nina Donkor, Suchismita Acharya
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	MDPI AG 2023-11-01
Σειρά:	Biomedicines
Θέματα:	nitric oxide reactive oxygen species glaucoma oxidative stress TEMPOL derivatives neuroprotection
Διαθέσιμο Online:	https://www.mdpi.com/2227-9059/11/11/2959

Παρόμοια τεκμήρια

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Tempol Mitigates Methotrexate-Induced Osteotoxicity via Oxidative Stress Modulation and MAPK Pathway Inhibition
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Έκδοση: (2025-02-01)

Tempol Protects Against Acetaminophen Induced Acute Hepatotoxicity by Inhibiting Oxidative Stress and Apoptosis
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Stable redox-cycling nitroxide Tempol inhibits NET formation
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Tempol Alters Antioxidant Enzyme Function, Modulates Multiple Genes Expression, and Ameliorates Hepatic and Renal Impairment in Carbon Tetrachloride (CCl<sub>4</sub>)-Intoxicated Rats
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Έκδοση: (2023-03-01)

Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained-mdx Mice
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Έκδοση: (2021-04-01)

Tempol Preserves Endothelial Progenitor Cells in Male Mice with Ambient Fine Particulate Matter Exposure
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Efficacy of the Radical Scavenger, Tempol, to Reduce Inflammation and Oxidative Stress in a Murine Model of Atopic Dermatitis
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Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker
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Έκδοση: (2024-02-01)

Systemic Administration of Tempol, a Superoxide Dismutase Mimetic, Augments Upper Airway Muscle Activity in Obese Zucker Rats
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Έκδοση: (2022-02-01)

Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect of TEMPOL in Zebrafish Model
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Έκδοση: (2021-01-01)

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Έκδοση: (2021-02-01)

Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl
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Έκδοση: (2021-06-01)

Tempol Inhibits the Growth of Lung Cancer and Normal Cells through Apoptosis Accompanied by Increased O<sub>2</sub><sup>•−</sup> Levels and Glutathione Depletion
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Tempol Reverses the Negative Effects of Morphine on Arterial Blood-Gas Chemistry and Tissue Oxygen Saturation in Freely-Moving Rats
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Έκδοση: (2021-09-01)

Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
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Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress
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In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue
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Έκδοση: (2021-11-01)

Neuroprotection of Rodent and Human Retinal Ganglion Cells In Vitro/Ex Vivo by the Hybrid Small Molecule SA-2
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Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway
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Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma
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Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
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Efficient Scavenging of TEMPOL Radical by Ascorbic Acid in Solution and Related Prolongation of <sup>13</sup>C and <sup>1</sup>H Nuclear Spin Relaxation Times of the Solute
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Comparative study between apocynin and protocatechuic acid regarding antioxidant capacity and vascular effects
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Έκδοση: (2022-11-01)

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Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3β Signaling Cascades and Afferent Arteriolar Activity
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Improving Endogenous Nitric Oxide Enhances Cadmium Tolerance in Rice through Modulation of Cadmium Accumulation and Antioxidant Capacity
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Έκδοση: (2023-07-01)

Nitric oxide levels in the aqueous humor vary in different ocular hypertension experimental models
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Έκδοση: (2014-12-01)

Tempol improves optic nerve histopathology and ultrastructures in cisplatin-induced optic neuropathy in rats by targeting oxidative stress—Endoplasmic reticulum stress—Autophagy signaling pathways
ανά: Amira Ebrahim Alsemeh, κ.ά.
Έκδοση: (2023-10-01)

Tempol Alters Urinary Extracellular Vesicle Lipid Content and Release While Reducing Blood Pressure during the Development of Salt-Sensitive Hypertension
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Έκδοση: (2021-12-01)

Nitric Oxide Interaction with the Eye
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Έκδοση: (2021-06-01)

Rapid Eye Movement sleep deprivation of rat generates ROS in the hepatocytes and makes them more susceptible to oxidative stress
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Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease
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Έκδοση: (2021-09-01)