Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression

Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression

Background: Pancreatic ductal adenocarcinoma (PDAC) is resistant to single-agent immunotherapies. To understand the mechanisms leading to the poor response to this treatment, a better understanding of the PDAC immune landscape is required. The present work aims to study the immune profile in PDAC in...

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Bibliographic Details
Main Authors: Alexandros Papalampros, Michail Vailas, Konstantinos Ntostoglou, Maria Lopez Chiloeches, Stratigoula Sakellariou, Niki V. Chouliari, Menelaos G. Samaras, Paraskevi D. Veltsista, Sofia D. P. Theodorou, Aggelos T. Margetis, Anna Bergonzini, Lysandros Karydakis, Natasha Hasemaki, Sophia Havaki, Ioannis I. Moustakas, Antonios Chatzigeorgiou, Timokratis Karamitros, Eleni Patsea, Christos Kittas, Andreas C. Lazaris, Evangelos Felekouras, Vassilis G. Gorgoulis, Teresa Frisan, Ioannis S. Pateras
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
spatial heterogeneity
draining lymph nodes
tumor microenvironment
T cell exhaustion
T cell senescence
Online Access:https://www.mdpi.com/2072-6694/12/7/1825

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