Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report
Abstract Background Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical p...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1071-6 |
| _version_ | 1828839210379902976 |
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| author | Vassilios Liakopoulos Panagiotis I Georgianos Paraskevi Demirtzi Vasilios Vaios Theofanis Kalathas Pantelis E Zebekakis |
| author_facet | Vassilios Liakopoulos Panagiotis I Georgianos Paraskevi Demirtzi Vasilios Vaios Theofanis Kalathas Pantelis E Zebekakis |
| author_sort | Vassilios Liakopoulos |
| collection | DOAJ |
| description | Abstract Background Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated with the appearance of skin rashes and other related skin reactions. Case presentation Herein, we report the rare case of a 91-year-old woman with a history of severe congestive heart failure, who initiated continuous ambulatory peritoneal dialysis with icodextrin-based dialysate solutions and 15 days after the initial exposure to icodextrin developed a generalized maculopapular and exfoliative skin rash extending over the back, torso and extremities. Discontinuation of icodextrin and oral therapy with low-dose methyl-prednisolone with quick dose tapering improved the skin lesions within the following days. Conclusions This case report highlights that skin hypersensitivity is a rare icodextrin-related adverse event that should be suspected in patients manifesting skin reactions typically within a few days or weeks after the initial exposure. |
| first_indexed | 2024-12-12T19:18:41Z |
| format | Article |
| id | doaj.art-dfc9257b7c8b442d807fae5c92d48283 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-12T19:18:41Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-dfc9257b7c8b442d807fae5c92d482832022-12-22T00:14:40ZengBMCBMC Nephrology1471-23692018-10-011911410.1186/s12882-018-1071-6Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-reportVassilios Liakopoulos0Panagiotis I Georgianos1Paraskevi Demirtzi2Vasilios Vaios3Theofanis Kalathas4Pantelis E Zebekakis5Peritoneal Dialysis Unit, 1st Department of Medicine, AHEPA Hospital, Aristotle University of ThessalonikiPeritoneal Dialysis Unit, 1st Department of Medicine, AHEPA Hospital, Aristotle University of ThessalonikiPeritoneal Dialysis Unit, 1st Department of Medicine, AHEPA Hospital, Aristotle University of ThessalonikiPeritoneal Dialysis Unit, 1st Department of Medicine, AHEPA Hospital, Aristotle University of ThessalonikiPeritoneal Dialysis Unit, 1st Department of Medicine, AHEPA Hospital, Aristotle University of ThessalonikiPeritoneal Dialysis Unit, 1st Department of Medicine, AHEPA Hospital, Aristotle University of ThessalonikiAbstract Background Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated with the appearance of skin rashes and other related skin reactions. Case presentation Herein, we report the rare case of a 91-year-old woman with a history of severe congestive heart failure, who initiated continuous ambulatory peritoneal dialysis with icodextrin-based dialysate solutions and 15 days after the initial exposure to icodextrin developed a generalized maculopapular and exfoliative skin rash extending over the back, torso and extremities. Discontinuation of icodextrin and oral therapy with low-dose methyl-prednisolone with quick dose tapering improved the skin lesions within the following days. Conclusions This case report highlights that skin hypersensitivity is a rare icodextrin-related adverse event that should be suspected in patients manifesting skin reactions typically within a few days or weeks after the initial exposure.http://link.springer.com/article/10.1186/s12882-018-1071-6IcodextrinHypersensitivityPeritoneal dialysisSkin rash |
| spellingShingle | Vassilios Liakopoulos Panagiotis I Georgianos Paraskevi Demirtzi Vasilios Vaios Theofanis Kalathas Pantelis E Zebekakis Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report BMC Nephrology Icodextrin Hypersensitivity Peritoneal dialysis Skin rash |
| title | Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report |
| title_full | Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report |
| title_fullStr | Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report |
| title_full_unstemmed | Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report |
| title_short | Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report |
| title_sort | icodextrin associated generalized exfoliative skin rash in a capd patient a case report |
| topic | Icodextrin Hypersensitivity Peritoneal dialysis Skin rash |
| url | http://link.springer.com/article/10.1186/s12882-018-1071-6 |
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