Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation

Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation

ABSTRACTShort-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandi...

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Main Authors: Ana Nogal, Francesco Asnicar, Amrita Vijay, Afroditi Kouraki, Alessia Visconti, Panayiotis Louca, Kari Wong, Andrei-Florin Baleanu, Francesca Giordano, Jonathan Wolf, George Hadjigeorgiou, Richard Davies, Gregory A. Michelotti, Paul W. Franks, Sarah E. Berry, Mario Falchi, Adeel Ikram, Benjamin J. Ollivere, Amy Zheng, Jessica Nightingale, Massimo Mangino, Nicola Segata, William J. Bulsiewicz, Tim D. Spector, Ana M. Valdes, Cristina Menni
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Short-chain fatty acids
postprandial
heritability
gut microbiota
inflammatory response
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2240050

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