Association of Urine sCD163 With Proliferative Lupus Nephritis, Fibrinoid Necrosis, Cellular Crescents and Intrarenal M2 Macrophages

Association of Urine sCD163 With Proliferative Lupus Nephritis, Fibrinoid Necrosis, Cellular Crescents and Intrarenal M2 Macrophages

CD163 is a marker for alternatively activated macrophages, which have been implicated in the pathogenesis of lupus nephritis (LN). In our preliminary screening of urine proteins in LN, urine soluble CD163 (sCD163) was significantly elevated in patients with active LN. To evaluate the potential of sC...

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Bibliographic Details
Main Authors: Ting Zhang, Hao Li, Kamala Vanarsa, Gabriel Gidley, Chi Chiu Mok, Michelle Petri, Ramesh Saxena, Chandra Mohan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
CD163
lupus nephritis
urine biomarker
renal pathology
activity index
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00671/full

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