Photostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cells
Abstract Magnetic nanoparticles have shown promise in various medical applications, including cancer treatment and diagnostics. The objective of this study is to attain mastery over the synthesis of silver nanoparticles (AgNPs), Cobalt silver nanocomposite (CoAgNC) and magnetite silver nanocomposite...
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| Format: | Article |
| Language: | English |
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Springer
2023-08-01
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| Series: | SN Applied Sciences |
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| Online Access: | https://doi.org/10.1007/s42452-023-05472-y |
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| author | Marwa A. Ramadan Tarek A. El-Tayeb |
| author_facet | Marwa A. Ramadan Tarek A. El-Tayeb |
| author_sort | Marwa A. Ramadan |
| collection | DOAJ |
| description | Abstract Magnetic nanoparticles have shown promise in various medical applications, including cancer treatment and diagnostics. The objective of this study is to attain mastery over the synthesis of silver nanoparticles (AgNPs), Cobalt silver nanocomposite (CoAgNC) and magnetite silver nanocomposite (IOAgNC), while also examining their photostability, cytotoxicity, and photothermal impact on Human Laryngeal Carcinoma Cell line (HEp-2). The preparation and characterization of AgNPs, CoAgNC, and IOAgNC were described, including the assessment of their photostability and cytotoxicity on HEp-2 cell line. The photostability of these nanomaterials was determined by subjecting them to different light sources, while their morphology and magnetic properties were characterized using a spectrophotometer, Transmission Electron Microscopy (TEM), and Vibrating Sample Magnetometer (VSM). The results of the characterization of AgNPs, CoAgNC, and IOAgNC showed that the prepared nanomaterials have distinct optical and morphological properties. The synthesized nanomaterials were stable in aqueous solutions and exhibited magnetic properties. The cytotoxicity tests on HEp-2 cells showed that the nanomaterials were not toxic in the dark, but their toxicity increased under light exposure, with IOAgNC showing the most significant toxicity. CoAgNC was found to be photostable under UV light and Light Emitting Diode (LED) irradiation due to the little lattice mismatch between cobalt and silver. Nanocomposite systems of high magnetic moment, such as IOAgNC and CoAgNC, have potential for tumor treatment through magnetic fluid hyperthermia. The photostability, chemical stability, and biocompatibility of AgNPs, CoAgNC, and IOAgNC were investigated and found to be non-toxic even at high concentrations. These nanomaterials have multiple optical and magnetic functionalities and are promising candidates for biomedical applications. |
| first_indexed | 2024-03-12T04:05:10Z |
| format | Article |
| id | doaj.art-dfcc8ca9671f440481a8613c0ff692b0 |
| institution | Directory Open Access Journal |
| issn | 2523-3963 2523-3971 |
| language | English |
| last_indexed | 2024-03-12T04:05:10Z |
| publishDate | 2023-08-01 |
| publisher | Springer |
| record_format | Article |
| series | SN Applied Sciences |
| spelling | doaj.art-dfcc8ca9671f440481a8613c0ff692b02023-09-03T11:21:52ZengSpringerSN Applied Sciences2523-39632523-39712023-08-015911210.1007/s42452-023-05472-yPhotostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cellsMarwa A. Ramadan0Tarek A. El-Tayeb1Department of Laser Application in Metrology Photochemistry and Agriculture, National Institute for Laser Enhanced Science (NILES), Cairo University (CU)Department of Laser Application in Metrology Photochemistry and Agriculture, National Institute for Laser Enhanced Science (NILES), Cairo University (CU)Abstract Magnetic nanoparticles have shown promise in various medical applications, including cancer treatment and diagnostics. The objective of this study is to attain mastery over the synthesis of silver nanoparticles (AgNPs), Cobalt silver nanocomposite (CoAgNC) and magnetite silver nanocomposite (IOAgNC), while also examining their photostability, cytotoxicity, and photothermal impact on Human Laryngeal Carcinoma Cell line (HEp-2). The preparation and characterization of AgNPs, CoAgNC, and IOAgNC were described, including the assessment of their photostability and cytotoxicity on HEp-2 cell line. The photostability of these nanomaterials was determined by subjecting them to different light sources, while their morphology and magnetic properties were characterized using a spectrophotometer, Transmission Electron Microscopy (TEM), and Vibrating Sample Magnetometer (VSM). The results of the characterization of AgNPs, CoAgNC, and IOAgNC showed that the prepared nanomaterials have distinct optical and morphological properties. The synthesized nanomaterials were stable in aqueous solutions and exhibited magnetic properties. The cytotoxicity tests on HEp-2 cells showed that the nanomaterials were not toxic in the dark, but their toxicity increased under light exposure, with IOAgNC showing the most significant toxicity. CoAgNC was found to be photostable under UV light and Light Emitting Diode (LED) irradiation due to the little lattice mismatch between cobalt and silver. Nanocomposite systems of high magnetic moment, such as IOAgNC and CoAgNC, have potential for tumor treatment through magnetic fluid hyperthermia. The photostability, chemical stability, and biocompatibility of AgNPs, CoAgNC, and IOAgNC were investigated and found to be non-toxic even at high concentrations. These nanomaterials have multiple optical and magnetic functionalities and are promising candidates for biomedical applications.https://doi.org/10.1007/s42452-023-05472-ySilver nanoparticles (AgNPs)Cobalt silver nanocomposite (CoAgNC)Magnetite silver nanocomposite (IOAgNC)PhotostabilityCytotoxicityPTT |
| spellingShingle | Marwa A. Ramadan Tarek A. El-Tayeb Photostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cells SN Applied Sciences Silver nanoparticles (AgNPs) Cobalt silver nanocomposite (CoAgNC) Magnetite silver nanocomposite (IOAgNC) Photostability Cytotoxicity PTT |
| title | Photostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cells |
| title_full | Photostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cells |
| title_fullStr | Photostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cells |
| title_full_unstemmed | Photostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cells |
| title_short | Photostability, cytotoxicity, and photothermal impact of AgNPs, CoAgNC, and IOAgNC on HEp-2 laryngeal carcinoma cells |
| title_sort | photostability cytotoxicity and photothermal impact of agnps coagnc and ioagnc on hep 2 laryngeal carcinoma cells |
| topic | Silver nanoparticles (AgNPs) Cobalt silver nanocomposite (CoAgNC) Magnetite silver nanocomposite (IOAgNC) Photostability Cytotoxicity PTT |
| url | https://doi.org/10.1007/s42452-023-05472-y |
| work_keys_str_mv | AT marwaaramadan photostabilitycytotoxicityandphotothermalimpactofagnpscoagncandioagnconhep2laryngealcarcinomacells AT tarekaeltayeb photostabilitycytotoxicityandphotothermalimpactofagnpscoagncandioagnconhep2laryngealcarcinomacells |