Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats
Abstract Background Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease and could be considered a metabolic disease because it is often accompanied by obesity and insulin resistance. Brown adipose tissue (BAT) transplantation has been shown to be effective in treating PCOS rats. Re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-024-01374-8 |
| _version_ | 1797273627830255616 |
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| author | Yan Yan Fangfang Di Ruoxi Zhang Liwen Song Runjie Zhang Jin Qiu |
| author_facet | Yan Yan Fangfang Di Ruoxi Zhang Liwen Song Runjie Zhang Jin Qiu |
| author_sort | Yan Yan |
| collection | DOAJ |
| description | Abstract Background Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease and could be considered a metabolic disease because it is often accompanied by obesity and insulin resistance. Brown adipose tissue (BAT) transplantation has been shown to be effective in treating PCOS rats. Results The study demonstrated that BAT successfully recovered the reproductive and metabolic phenotype of PCOS rats. The disorder estrous cycle, abnormal hyperglycemia and the expression of liver factors were improved. Differentially expressed metabolites were analyzed, among them, arachidonic acid may play a role in inhibiting cell proliferation, enhancing oxidative stress reaction, promoting estrogen expression, and reducing progesterone level in KGN cells. Conclusion Our findings suggest that BAT transplantation may be a therapeutic strategy for PCOS by changing the expression of some cytokines and metabolites. Differentially expressed metabolites might be crucially important for the pathogenesis of PCOS. |
| first_indexed | 2024-03-07T14:47:07Z |
| format | Article |
| id | doaj.art-dfd0bd826c564978b6b311e8050ef31b |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-03-07T14:47:07Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-dfd0bd826c564978b6b311e8050ef31b2024-03-05T19:58:08ZengBMCJournal of Ovarian Research1757-22152024-02-0117111410.1186/s13048-024-01374-8Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation ratsYan Yan0Fangfang Di1Ruoxi Zhang2Liwen Song3Runjie Zhang4Jin Qiu5Obstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of MedicineObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of MedicineObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of MedicineObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of MedicineObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of MedicineObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease and could be considered a metabolic disease because it is often accompanied by obesity and insulin resistance. Brown adipose tissue (BAT) transplantation has been shown to be effective in treating PCOS rats. Results The study demonstrated that BAT successfully recovered the reproductive and metabolic phenotype of PCOS rats. The disorder estrous cycle, abnormal hyperglycemia and the expression of liver factors were improved. Differentially expressed metabolites were analyzed, among them, arachidonic acid may play a role in inhibiting cell proliferation, enhancing oxidative stress reaction, promoting estrogen expression, and reducing progesterone level in KGN cells. Conclusion Our findings suggest that BAT transplantation may be a therapeutic strategy for PCOS by changing the expression of some cytokines and metabolites. Differentially expressed metabolites might be crucially important for the pathogenesis of PCOS.https://doi.org/10.1186/s13048-024-01374-8PCOSBATGranulosa cellsArachidonic acidMetabolitesLiver factor |
| spellingShingle | Yan Yan Fangfang Di Ruoxi Zhang Liwen Song Runjie Zhang Jin Qiu Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats Journal of Ovarian Research PCOS BAT Granulosa cells Arachidonic acid Metabolites Liver factor |
| title | Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats |
| title_full | Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats |
| title_fullStr | Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats |
| title_full_unstemmed | Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats |
| title_short | Arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats |
| title_sort | arachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats |
| topic | PCOS BAT Granulosa cells Arachidonic acid Metabolites Liver factor |
| url | https://doi.org/10.1186/s13048-024-01374-8 |
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