Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13135 |
| _version_ | 1830416988722167808 |
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| author | Awani Upadhyay Aditya Pisupati Timothy Jegla Matt Crook Keith J. Mickolajczyk Matthew Shorey Laura E. Rohan Katherine A. Billings Melissa M. Rolls William O. Hancock Wendy Hanna-Rose |
| author_facet | Awani Upadhyay Aditya Pisupati Timothy Jegla Matt Crook Keith J. Mickolajczyk Matthew Shorey Laura E. Rohan Katherine A. Billings Melissa M. Rolls William O. Hancock Wendy Hanna-Rose |
| author_sort | Awani Upadhyay |
| collection | DOAJ |
| description | TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity. |
| first_indexed | 2024-12-20T21:34:13Z |
| format | Article |
| id | doaj.art-dfd0ef3108b94258be603a05f7ad9bb7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:34:13Z |
| publishDate | 2016-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dfd0ef3108b94258be603a05f7ad9bb72022-12-21T19:25:59ZengNature PortfolioNature Communications2041-17232016-10-017111110.1038/ncomms13135Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channelAwani Upadhyay0Aditya Pisupati1Timothy Jegla2Matt Crook3Keith J. Mickolajczyk4Matthew Shorey5Laura E. Rohan6Katherine A. Billings7Melissa M. Rolls8William O. Hancock9Wendy Hanna-Rose10Department of Biochemistry and Molecular Biology, The Pennsylvania State UniversityDepartment of Biology, The Pennsylvania State UniversityDepartment of Biology, The Pennsylvania State UniversityDepartment of Biochemistry and Molecular Biology, The Pennsylvania State UniversityDepartment of Biomedical Engineering, The Pennsylvania State UniversityDepartment of Biochemistry and Molecular Biology, The Pennsylvania State UniversityDepartment of Biochemistry and Molecular Biology, The Pennsylvania State UniversityDepartment of Biology, The Pennsylvania State UniversityDepartment of Biochemistry and Molecular Biology, The Pennsylvania State UniversityDepartment of Biomedical Engineering, The Pennsylvania State UniversityDepartment of Biochemistry and Molecular Biology, The Pennsylvania State UniversityTRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.https://doi.org/10.1038/ncomms13135 |
| spellingShingle | Awani Upadhyay Aditya Pisupati Timothy Jegla Matt Crook Keith J. Mickolajczyk Matthew Shorey Laura E. Rohan Katherine A. Billings Melissa M. Rolls William O. Hancock Wendy Hanna-Rose Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel Nature Communications |
| title | Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel |
| title_full | Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel |
| title_fullStr | Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel |
| title_full_unstemmed | Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel |
| title_short | Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel |
| title_sort | nicotinamide is an endogenous agonist for a c elegans trpv osm 9 and ocr 4 channel |
| url | https://doi.org/10.1038/ncomms13135 |
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