Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle>
Tick-borne encephalitis virus (TBEV) causes mild or moderate febrile illness in humans that may progress to encephalitis, leading to severe long-term complications and sometimes death. TBEV is prevalent in the Eurasian continent and has been isolated in China, Japan and Republic of Korea (ROK). The...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2017.69 |
| _version_ | 1827809108092256256 |
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| author | Kentaro Yoshii Joon Young Song Seong-Beom Park Junfeng Yang Heinz-Josef Schmitt |
| author_facet | Kentaro Yoshii Joon Young Song Seong-Beom Park Junfeng Yang Heinz-Josef Schmitt |
| author_sort | Kentaro Yoshii |
| collection | DOAJ |
| description | Tick-borne encephalitis virus (TBEV) causes mild or moderate febrile illness in humans that may progress to encephalitis, leading to severe long-term complications and sometimes death. TBEV is prevalent in the Eurasian continent and has been isolated in China, Japan and Republic of Korea (ROK). The TBEV isolates from Japan are of the Far-Eastern subtype; in ROK, the isolates are of the Western subtype; and all TBEV isolates in China are of the Far-Eastern subtype, except one strain that was identified most recently as the Siberian subtype. TBE is endemic to the northeast, northwest and southeast of China; only two confirmed TBE cases have been reported in Japan to date; and no TBE case has been confirmed in ROK. For TBE patients in China, the onset of disease is acute with no biphasic course for disease presentation. The clinical spectrum of disease phenotypes may be wider than currently understood, since serological evidence suggests the presence of TBEV infections in healthy people, indicating that asymptomatic or unspecific manifestations of TBEV infection may exist. The current treatment for TBE is supportive care. In China, vaccines against TBEV have been developed and are available with demonstrated immunogenicity and safety, although efficacy data are lacking. No vaccines are available in ROK or Japan.Emerging Microbes & Infections (2017) 6, e82; doi:10.1038/emi.2017.69; published online 20 September 2017 |
| first_indexed | 2024-03-11T22:37:20Z |
| format | Article |
| id | doaj.art-dfd13339b1f648ad9df0ae106664337b |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T22:37:20Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-dfd13339b1f648ad9df0ae106664337b2023-09-22T12:08:35ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512017-01-016111010.1038/emi.2017.69Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle>Kentaro Yoshii0Joon Young Song1Seong-Beom Park2Junfeng Yang3Heinz-Josef Schmitt4Laboratory of Public Health, Graduate School of Veterinary MedicineHokkaido University, Sapporo 060-0818, JapanDivision of Infectious Diseases, Department of Internal MedicineKorea University Guro Hospital, Gurodongro 148, Gurogu, Seoul 08308, Republic of KoreaPfizer Pharmaceuticals Korea Ltd, Seoul 100-771, Republic of KoreaPfizer Investment Co., Ltd. The Fifth Square, Tower B, 9/F, No. 3-7, Chaoyangmen North Avenue, Dongcheng District, Beijing 100010, ChinaScientific Affairs, Pfizer Vaccines Europe, 23-25 Avenue du Dr Lannelongue, Paris 75014, FranceTick-borne encephalitis virus (TBEV) causes mild or moderate febrile illness in humans that may progress to encephalitis, leading to severe long-term complications and sometimes death. TBEV is prevalent in the Eurasian continent and has been isolated in China, Japan and Republic of Korea (ROK). The TBEV isolates from Japan are of the Far-Eastern subtype; in ROK, the isolates are of the Western subtype; and all TBEV isolates in China are of the Far-Eastern subtype, except one strain that was identified most recently as the Siberian subtype. TBE is endemic to the northeast, northwest and southeast of China; only two confirmed TBE cases have been reported in Japan to date; and no TBE case has been confirmed in ROK. For TBE patients in China, the onset of disease is acute with no biphasic course for disease presentation. The clinical spectrum of disease phenotypes may be wider than currently understood, since serological evidence suggests the presence of TBEV infections in healthy people, indicating that asymptomatic or unspecific manifestations of TBEV infection may exist. The current treatment for TBE is supportive care. In China, vaccines against TBEV have been developed and are available with demonstrated immunogenicity and safety, although efficacy data are lacking. No vaccines are available in ROK or Japan.Emerging Microbes & Infections (2017) 6, e82; doi:10.1038/emi.2017.69; published online 20 September 2017https://www.tandfonline.com/doi/10.1038/emi.2017.69East Asiatick-borne encephalitistick-borne encephalitis virus |
| spellingShingle | Kentaro Yoshii Joon Young Song Seong-Beom Park Junfeng Yang Heinz-Josef Schmitt Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle> Emerging Microbes and Infections East Asia tick-borne encephalitis tick-borne encephalitis virus |
| title | Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle> |
| title_full | Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle> |
| title_fullStr | Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle> |
| title_full_unstemmed | Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle> |
| title_short | Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle> |
| title_sort | tick borne encephalitis in japan republic of korea and china subtitle tbe in japan rok and china subtitle |
| topic | East Asia tick-borne encephalitis tick-borne encephalitis virus |
| url | https://www.tandfonline.com/doi/10.1038/emi.2017.69 |
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