Sprouty1 regulates gonadal white adipose tissue growth through a PDGFRα/β-Akt pathway

Sprouty1 regulates gonadal white adipose tissue growth through a PDGFRα/β-Akt pathway

Expansion of visceral white adipose tissue (vWAT) occurs in response to nutrient excess, and is a risk factor for metabolic disease. SPRY1, a feedback inhibitor of receptor tyrosine kinase (RTK) signaling, is expressed in PDGFRa+ adipocyte progenitor cells (APC) in vivo. Global deficiency of Spry1 i...

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Bibliographic Details
Main Authors: Xuehui Yang, Shivangi Pande, Robert A. Koza, Robert Friesel
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Adipocyte
Subjects:
adipocyte
sprouty1
proliferation
differentiation
fibrosis
cell signalling
Online Access:http://dx.doi.org/10.1080/21623945.2021.1987634

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