Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer
The mechanism of how VEGF-C is regulated to promote lymphatic metastasis of oesophageal cancer is unclear. Here the authors show that nicotine prevents the mRNA decay of VEGF-C mRNA and promotes lymphatic metastasis by downregulating deubiquitinase OTUD3 and RNA binding protein ZFP36.
| Main Authors: | , , , , , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Nature Portfolio
2021-12-01
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| 丛编: | Nature Communications |
| 在线阅读: | https://doi.org/10.1038/s41467-021-27348-8 |