PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway

PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway

Protein arginine methyltransferase 1 (PRMT1), a type I PRMT, is overexpressed in gastric cancer (GC) cells. To elucidate the function of PRMT1 in GC, PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hairpin RNA (shRNA) or inhibited by PRMT1 inhibitors (AMI-1 or DCLX069), which r...

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Bibliografische gegevens
Hoofdauteurs: Feng Wang, Shitong Chen, Shihan Peng, Xujun Zhou, Houyi Tang, Hanghua Liang, Xi Zhong, He Yang, Xiaoxue Ke, MuHan Lü, Hongjuan Cui
Formaat: Artikel
Taal:English
Gepubliceerd in: KeAi Communications Co., Ltd. 2023-11-01
Reeks:Genes and Diseases
Onderwerpen:
β-catenin signaling pathway
Gastric cancer
PRMT1
Transcriptional regulation
Ubiquitination
Online toegang:http://www.sciencedirect.com/science/article/pii/S2352304223000508

Internet

http://www.sciencedirect.com/science/article/pii/S2352304223000508

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