High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma
High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose che...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/3/837 |
| _version_ | 1797488679009124352 |
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| author | Lucie Lafay-Cousin Christelle Dufour |
| author_facet | Lucie Lafay-Cousin Christelle Dufour |
| author_sort | Lucie Lafay-Cousin |
| collection | DOAJ |
| description | High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribution to improved survival and describe their toxicity profile and limitations. |
| first_indexed | 2024-03-10T00:05:46Z |
| format | Article |
| id | doaj.art-dfd3e301bbea4fa5adb138d1cbe787a4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:05:46Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dfd3e301bbea4fa5adb138d1cbe787a42023-11-23T16:09:29ZengMDPI AGCancers2072-66942022-02-0114383710.3390/cancers14030837High-Dose Chemotherapy in Children with Newly Diagnosed MedulloblastomaLucie Lafay-Cousin0Christelle Dufour1Section of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children’s Hospital, Calgary, AB T3B 6A8, CanadaDepartment of Pediatric and Adolescent Oncology, Gustave Roussy, 96805 Villejuif, FranceHigh-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribution to improved survival and describe their toxicity profile and limitations.https://www.mdpi.com/2072-6694/14/3/837newly diagnosed medulloblastomachildhoodhigh-dose chemotherapytrials |
| spellingShingle | Lucie Lafay-Cousin Christelle Dufour High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma Cancers newly diagnosed medulloblastoma childhood high-dose chemotherapy trials |
| title | High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma |
| title_full | High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma |
| title_fullStr | High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma |
| title_full_unstemmed | High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma |
| title_short | High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma |
| title_sort | high dose chemotherapy in children with newly diagnosed medulloblastoma |
| topic | newly diagnosed medulloblastoma childhood high-dose chemotherapy trials |
| url | https://www.mdpi.com/2072-6694/14/3/837 |
| work_keys_str_mv | AT lucielafaycousin highdosechemotherapyinchildrenwithnewlydiagnosedmedulloblastoma AT christelledufour highdosechemotherapyinchildrenwithnewlydiagnosedmedulloblastoma |