Development of an Efficient, High Purity Continuous Flow Synthesis of Diazepam

Development of an Efficient, High Purity Continuous Flow Synthesis of Diazepam

In an effort to strengthen the resiliency of supply chains for active pharmaceutical ingredients (API), continuous manufacturing processes may be optimized with respect to improved chemoselectivity, production rate, yield, and/or process intensity. We report an efficient two-step continuous flow syn...

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Bibliographic Details
Main Authors:	Robert J. Nicholas, Michael A. McGuire, Seok-Hee Hyun, Madeline N. Cullison, David H. Thompson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Chemical Engineering
Subjects:	diazepam benzodiazepine continuous syntheses reaction scale-up common ion effect process optimization
Online Access:	https://www.frontiersin.org/articles/10.3389/fceng.2022.877498/full

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