Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model

Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model

ObjectivesThe histidine kinase (HK) CHK1 and other protein kinases in Candida albicans are key players in the development of hyphae. This study is designed to determine the functional roles of the S_Tkc domain (protein kinase) and the GAF domain of C. albicans CHK1 in hyphal formation and mucosal in...

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Bibliographic Details
Main Authors: Yahui Feng, Shaodong Bian, Zhiping Pang, Yiyang Wen, Richard Calderone, Dongmei Li, Dongmei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Microbiology
Subjects:
histidine kinase
Candida albicans
two-component signal transduction
fungal mucosal model
infectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.855651/full

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