Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells

Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells

Multivesicular bodies (MVB) are endocytic compartments that enclose intraluminal vesicles (ILVs) formed by inward budding from the limiting membrane of endosomes. In T lymphocytes, ILVs are secreted as Fas ligand-bearing, pro-apoptotic exosomes following T cell receptor (TCR)-induced fusion of MVB w...

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Bibliographic Details
Main Authors: Gonzalo Herranz, Pablo Aguilera, Sergio Dávila, Alicia Sánchez, Bianca Stancu, Jesús Gómez, David Fernández-Moreno, Raúl de Martín, Mario Quintanilla, Teresa Fernández, Pablo Rodríguez-Silvestre, Laura Márquez-Expósito, Ana Bello-Gamboa, Alberto Fraile-Ramos, Víctor Calvo, Manuel Izquierdo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
T lymphocytes
immune synapse
protein kinase C δ
multivesicular bodies
exosomes
cytotoxic activity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00851/full

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