Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells
Multivesicular bodies (MVB) are endocytic compartments that enclose intraluminal vesicles (ILVs) formed by inward budding from the limiting membrane of endosomes. In T lymphocytes, ILVs are secreted as Fas ligand-bearing, pro-apoptotic exosomes following T cell receptor (TCR)-induced fusion of MVB w...
Main Authors: | Gonzalo Herranz, Pablo Aguilera, Sergio Dávila, Alicia Sánchez, Bianca Stancu, Jesús Gómez, David Fernández-Moreno, Raúl de Martín, Mario Quintanilla, Teresa Fernández, Pablo Rodríguez-Silvestre, Laura Márquez-Expósito, Ana Bello-Gamboa, Alberto Fraile-Ramos, Víctor Calvo, Manuel Izquierdo |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-04-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00851/full |
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