Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome
Women with polycystic ovary syndrome (PCOS) tend to have elevated anti-Müllerian hormone (AMH) levels, which appear to correlate with disease severity and pregnancy outcomes. This was a retrospective observational study designed to assess the relationship between circulating AMH levels and in vitro...
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MDPI AG
2023-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/12/3150 |
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| author | Emídio Vale-Fernandes Márcia Barreiro Carla Leal Rosa Zulmira Macedo António Tomé Mariana P. Monteiro |
| author_facet | Emídio Vale-Fernandes Márcia Barreiro Carla Leal Rosa Zulmira Macedo António Tomé Mariana P. Monteiro |
| author_sort | Emídio Vale-Fernandes |
| collection | DOAJ |
| description | Women with polycystic ovary syndrome (PCOS) tend to have elevated anti-Müllerian hormone (AMH) levels, which appear to correlate with disease severity and pregnancy outcomes. This was a retrospective observational study designed to assess the relationship between circulating AMH levels and in vitro fertilization (IVF) outcomes. The study involved 150 women with PCOS who underwent IVF treatments. The women’s IVF cycles were allocated into three subgroups according to AMH levels: ‘low’ (AMH < 3.7 ng/mL; <i>n</i> = 49), ‘middle’ (AMH 3.7–7.4 ng/mL; <i>n</i> = 94), and ‘high’ (AMH > 7.4 ng/mL; <i>n</i> = 56). All pregnancy-related outcomes (positive beta human chorionic gonadotropin (βHCG), clinical pregnancy rate, live birth rate, and cumulative live birth rate) were greater in women’s IVF cycles with ‘low’ AMH when compared to those with ‘middle’ or ‘high’ AMH (<i>p</i> < 0.05). AMH levels below 3.7 ng/mL were found to be associated with lower oocyte immaturity rate and better pregnancy outcomes, although baseline AMH was not shown to have any significant predictive power for live birth and cumulative live birth in the multivariable logistic regression analysis after adjusting for possible confounders nor in the ROC analyses. In summary, the current study lays the groundwork to validate high AMH levels as a poor prognostic factor for pregnancy outcomes after IVF in women with PCOS. |
| first_indexed | 2024-03-08T20:59:07Z |
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| language | English |
| last_indexed | 2024-03-08T20:59:07Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj.art-dfd48d80976540948db05ccb687caf782023-12-22T13:54:48ZengMDPI AGBiomedicines2227-90592023-11-011112315010.3390/biomedicines11123150Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary SyndromeEmídio Vale-Fernandes0Márcia Barreiro1Carla Leal2Rosa Zulmira Macedo3António Tomé4Mariana P. Monteiro5Centre for Medically Assisted Procreation/Public Gamete Bank, Gynaecology Department, Centro Materno-Infantil do Norte Dr. Albino Aroso (CMIN), Centro Hospitalar Universitário de Santo António (CHUdSA), 4050-651 Porto, PortugalCentre for Medically Assisted Procreation/Public Gamete Bank, Gynaecology Department, Centro Materno-Infantil do Norte Dr. Albino Aroso (CMIN), Centro Hospitalar Universitário de Santo António (CHUdSA), 4050-651 Porto, PortugalCentre for Medically Assisted Procreation/Public Gamete Bank, Gynaecology Department, Centro Materno-Infantil do Norte Dr. Albino Aroso (CMIN), Centro Hospitalar Universitário de Santo António (CHUdSA), 4050-651 Porto, PortugalGynaecology Department, Centro Materno-Infantil do Norte Dr. Albino Aroso (CMIN), Centro Hospitalar Universitário de Santo António (CHUdSA), 4050-651 Porto, PortugalGynaecology Department, Centro Materno-Infantil do Norte Dr. Albino Aroso (CMIN), Centro Hospitalar Universitário de Santo António (CHUdSA), 4050-651 Porto, PortugalUMIB—Unit for Multidisciplinary Research in Biomedicine, ICBAS—School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalWomen with polycystic ovary syndrome (PCOS) tend to have elevated anti-Müllerian hormone (AMH) levels, which appear to correlate with disease severity and pregnancy outcomes. This was a retrospective observational study designed to assess the relationship between circulating AMH levels and in vitro fertilization (IVF) outcomes. The study involved 150 women with PCOS who underwent IVF treatments. The women’s IVF cycles were allocated into three subgroups according to AMH levels: ‘low’ (AMH < 3.7 ng/mL; <i>n</i> = 49), ‘middle’ (AMH 3.7–7.4 ng/mL; <i>n</i> = 94), and ‘high’ (AMH > 7.4 ng/mL; <i>n</i> = 56). All pregnancy-related outcomes (positive beta human chorionic gonadotropin (βHCG), clinical pregnancy rate, live birth rate, and cumulative live birth rate) were greater in women’s IVF cycles with ‘low’ AMH when compared to those with ‘middle’ or ‘high’ AMH (<i>p</i> < 0.05). AMH levels below 3.7 ng/mL were found to be associated with lower oocyte immaturity rate and better pregnancy outcomes, although baseline AMH was not shown to have any significant predictive power for live birth and cumulative live birth in the multivariable logistic regression analysis after adjusting for possible confounders nor in the ROC analyses. In summary, the current study lays the groundwork to validate high AMH levels as a poor prognostic factor for pregnancy outcomes after IVF in women with PCOS.https://www.mdpi.com/2227-9059/11/12/3150in vitro fertilization (IVF)anti-Müllerian hormone (AMH)polycystic ovary syndrome (PCOS)live birth ratecumulative live birth rate |
| spellingShingle | Emídio Vale-Fernandes Márcia Barreiro Carla Leal Rosa Zulmira Macedo António Tomé Mariana P. Monteiro Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome Biomedicines in vitro fertilization (IVF) anti-Müllerian hormone (AMH) polycystic ovary syndrome (PCOS) live birth rate cumulative live birth rate |
| title | Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome |
| title_full | Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome |
| title_fullStr | Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome |
| title_short | Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome |
| title_sort | elevated anti mullerian hormone as a prognostic factor for poor outcomes of in vitro fertilization in women with polycystic ovary syndrome |
| topic | in vitro fertilization (IVF) anti-Müllerian hormone (AMH) polycystic ovary syndrome (PCOS) live birth rate cumulative live birth rate |
| url | https://www.mdpi.com/2227-9059/11/12/3150 |
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