Three decades of Cdk5
Abstract Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of action, and its effects on the nervous system have...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-021-00774-y |
| _version_ | 1818721874680479744 |
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| author | Ping-Chieh Pao Li-Huei Tsai |
| author_facet | Ping-Chieh Pao Li-Huei Tsai |
| author_sort | Ping-Chieh Pao |
| collection | DOAJ |
| description | Abstract Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of action, and its effects on the nervous system have been a great focus in the field for nearly three decades. In this review, we provide an overview of the discovery and regulation of Cdk5, highlighting recent findings revealing its role in neuronal/synaptic functions, circadian clocks, DNA damage, cell cycle reentry, mitochondrial dysfunction, as well as its non-neuronal functions under physiological and pathological conditions. Moreover, we discuss evidence underscoring aberrant Cdk5 activity as a common theme observed in many neurodegenerative diseases. |
| first_indexed | 2024-12-17T20:45:40Z |
| format | Article |
| id | doaj.art-dfd4c72762814078a5665ef7d1a37a87 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-12-17T20:45:40Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-dfd4c72762814078a5665ef7d1a37a872022-12-21T21:33:10ZengBMCJournal of Biomedical Science1423-01272021-11-0128111710.1186/s12929-021-00774-yThree decades of Cdk5Ping-Chieh Pao0Li-Huei Tsai1Picower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyAbstract Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of action, and its effects on the nervous system have been a great focus in the field for nearly three decades. In this review, we provide an overview of the discovery and regulation of Cdk5, highlighting recent findings revealing its role in neuronal/synaptic functions, circadian clocks, DNA damage, cell cycle reentry, mitochondrial dysfunction, as well as its non-neuronal functions under physiological and pathological conditions. Moreover, we discuss evidence underscoring aberrant Cdk5 activity as a common theme observed in many neurodegenerative diseases.https://doi.org/10.1186/s12929-021-00774-yCdk5p35p25NeurodegenerationAlzheimer’s disease |
| spellingShingle | Ping-Chieh Pao Li-Huei Tsai Three decades of Cdk5 Journal of Biomedical Science Cdk5 p35 p25 Neurodegeneration Alzheimer’s disease |
| title | Three decades of Cdk5 |
| title_full | Three decades of Cdk5 |
| title_fullStr | Three decades of Cdk5 |
| title_full_unstemmed | Three decades of Cdk5 |
| title_short | Three decades of Cdk5 |
| title_sort | three decades of cdk5 |
| topic | Cdk5 p35 p25 Neurodegeneration Alzheimer’s disease |
| url | https://doi.org/10.1186/s12929-021-00774-y |
| work_keys_str_mv | AT pingchiehpao threedecadesofcdk5 AT lihueitsai threedecadesofcdk5 |