Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy
<i>Background and Objectives:</i> Functional mitral regurgitation (F-MR) observed in patients with atrial fibrillation could affect the effectiveness of the sinus rhythm restoring procedures. The aim of the study was to evaluate the impact of F-MR on pulmonary vein isolation (PVI) effica...
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MDPI AG
2021-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/798 |
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| author | Małgorzata Cichoń Maciej Wybraniec Magdalena Mizia-Szubryt Katarzyna Mizia-Stec |
| author_facet | Małgorzata Cichoń Maciej Wybraniec Magdalena Mizia-Szubryt Katarzyna Mizia-Stec |
| author_sort | Małgorzata Cichoń |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Functional mitral regurgitation (F-MR) observed in patients with atrial fibrillation could affect the effectiveness of the sinus rhythm restoring procedures. The aim of the study was to evaluate the impact of F-MR on pulmonary vein isolation (PVI) efficacy in patient with preserved ejection fraction (EF). <i>Materials and Methods:</i> One hundred and thirty-six patients with EF ≥ 50% (65.4% males; mean age 56 ± 11 years) with symptomatic paroxysmal or persistent AF qualified for PVI were enrolled into the study. F-MR assessment was performed in transthoracic (TTE) and transesophageal (TEE) echocardiography before the PVI procedure. PVI efficacy was evaluated in three-month and long-term follow-up. <i>Results:</i> F-MR was diagnosed in 74.3% patient in transthoracic echocardiography (TTE) (trace: 26.5%, mild: 43.4%, moderate: 3.7%, severe 0.7%) and 94.9% in transesophageal echocardiography (TEE) (trace: 17.6%, mild: 59.6%, moderate: 16.2%, severe: 1.5%). The PVI three-month efficacy was 75.7% in the three-month and 64% in the long-term observation. Severe F-MR in TEE at baseline was associated with lower three-month PVI efficacy (<i>p</i> = 0.012), while moderate to severe F-MR in TEE was related to inefficient PVI assessed in long-term follow-up (<i>p</i> = 0.041). <i>Conclusions:</i> Significant F-MR confirmed by TEE predicts three-month as well as long-term PVI efficacy. |
| first_indexed | 2024-03-10T08:37:32Z |
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| language | English |
| last_indexed | 2024-03-10T08:37:32Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-dfd5c8ba79b04887b403747b4b62f1fe2023-11-22T08:36:16ZengMDPI AGMedicina1010-660X1648-91442021-08-0157879810.3390/medicina57080798Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation EfficacyMałgorzata Cichoń0Maciej Wybraniec1Magdalena Mizia-Szubryt2Katarzyna Mizia-Stec3First Department of Cardiology, Medical University of Silesia, 40-635 Katowice, PolandFirst Department of Cardiology, Medical University of Silesia, 40-635 Katowice, PolandFirst Department of Cardiology, Medical University of Silesia, 40-635 Katowice, PolandFirst Department of Cardiology, Medical University of Silesia, 40-635 Katowice, Poland<i>Background and Objectives:</i> Functional mitral regurgitation (F-MR) observed in patients with atrial fibrillation could affect the effectiveness of the sinus rhythm restoring procedures. The aim of the study was to evaluate the impact of F-MR on pulmonary vein isolation (PVI) efficacy in patient with preserved ejection fraction (EF). <i>Materials and Methods:</i> One hundred and thirty-six patients with EF ≥ 50% (65.4% males; mean age 56 ± 11 years) with symptomatic paroxysmal or persistent AF qualified for PVI were enrolled into the study. F-MR assessment was performed in transthoracic (TTE) and transesophageal (TEE) echocardiography before the PVI procedure. PVI efficacy was evaluated in three-month and long-term follow-up. <i>Results:</i> F-MR was diagnosed in 74.3% patient in transthoracic echocardiography (TTE) (trace: 26.5%, mild: 43.4%, moderate: 3.7%, severe 0.7%) and 94.9% in transesophageal echocardiography (TEE) (trace: 17.6%, mild: 59.6%, moderate: 16.2%, severe: 1.5%). The PVI three-month efficacy was 75.7% in the three-month and 64% in the long-term observation. Severe F-MR in TEE at baseline was associated with lower three-month PVI efficacy (<i>p</i> = 0.012), while moderate to severe F-MR in TEE was related to inefficient PVI assessed in long-term follow-up (<i>p</i> = 0.041). <i>Conclusions:</i> Significant F-MR confirmed by TEE predicts three-month as well as long-term PVI efficacy.https://www.mdpi.com/1648-9144/57/8/798functional mitral regurgitationatrial fibrillationpulmonary vein isolationablation efficacysinus rhythm maintenance |
| spellingShingle | Małgorzata Cichoń Maciej Wybraniec Magdalena Mizia-Szubryt Katarzyna Mizia-Stec Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy Medicina functional mitral regurgitation atrial fibrillation pulmonary vein isolation ablation efficacy sinus rhythm maintenance |
| title | Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy |
| title_full | Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy |
| title_fullStr | Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy |
| title_full_unstemmed | Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy |
| title_short | Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy |
| title_sort | functional mitral regurgitation in patients with preserved ejection fraction qualified for pulmonary vein isolation a negative prognostic factor for catheter ablation efficacy |
| topic | functional mitral regurgitation atrial fibrillation pulmonary vein isolation ablation efficacy sinus rhythm maintenance |
| url | https://www.mdpi.com/1648-9144/57/8/798 |
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