The effects of estrogen on targeted cancer therapy drugs
Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions. Interestingly, estrogen has shown to be vital for the activity...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661822000767 |
| _version_ | 1797366693153996800 |
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| author | Ying Zhao Xin Wang Yi Liu Hao-Yu Wang Jin Xiang |
| author_facet | Ying Zhao Xin Wang Yi Liu Hao-Yu Wang Jin Xiang |
| author_sort | Ying Zhao |
| collection | DOAJ |
| description | Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions. Interestingly, estrogen has shown to be vital for the activity of some anticancer drugs, such as adriamycin, cisplatin, olaparib, trastuzumab, bevacizumab, tamoxifen, cyclophosphamide, methotrexate, and paclitaxel. Although there are many reasons for the differences in therapeutic effects among cancer patients, estrogen status is undoubtedly a very important factor. In view of the importance of the crosstalk between estrogen signaling and drug therapy for cancer, this review summarizes the effects of estrogen on the targets, metabolism and resistance of anticancer drugs and describes the related pathways and underlying mechanisms. Here, an analysis of the close relationship between estrogen and cancer drug therapy was conducted to clarify the effects of estrogen on the therapeutic efficacy of anticancer drugs to facilitate the future development of specific drug treatment strategies to achieve optimal outcomes. |
| first_indexed | 2024-03-08T17:07:22Z |
| format | Article |
| id | doaj.art-dfd617f9996847eba67ee2739243b9bf |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-08T17:07:22Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-dfd617f9996847eba67ee2739243b9bf2024-01-04T04:36:31ZengElsevierPharmacological Research1096-11862022-03-01177106131The effects of estrogen on targeted cancer therapy drugsYing Zhao0Xin Wang1Yi Liu2Hao-Yu Wang3Jin Xiang4Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR ChinaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR ChinaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR ChinaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR ChinaCorresponding author.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR ChinaImproving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions. Interestingly, estrogen has shown to be vital for the activity of some anticancer drugs, such as adriamycin, cisplatin, olaparib, trastuzumab, bevacizumab, tamoxifen, cyclophosphamide, methotrexate, and paclitaxel. Although there are many reasons for the differences in therapeutic effects among cancer patients, estrogen status is undoubtedly a very important factor. In view of the importance of the crosstalk between estrogen signaling and drug therapy for cancer, this review summarizes the effects of estrogen on the targets, metabolism and resistance of anticancer drugs and describes the related pathways and underlying mechanisms. Here, an analysis of the close relationship between estrogen and cancer drug therapy was conducted to clarify the effects of estrogen on the therapeutic efficacy of anticancer drugs to facilitate the future development of specific drug treatment strategies to achieve optimal outcomes.http://www.sciencedirect.com/science/article/pii/S1043661822000767EstrogenAnticancer drugsEstrogen receptorsMetabolismPrecision therapyResistance |
| spellingShingle | Ying Zhao Xin Wang Yi Liu Hao-Yu Wang Jin Xiang The effects of estrogen on targeted cancer therapy drugs Pharmacological Research Estrogen Anticancer drugs Estrogen receptors Metabolism Precision therapy Resistance |
| title | The effects of estrogen on targeted cancer therapy drugs |
| title_full | The effects of estrogen on targeted cancer therapy drugs |
| title_fullStr | The effects of estrogen on targeted cancer therapy drugs |
| title_full_unstemmed | The effects of estrogen on targeted cancer therapy drugs |
| title_short | The effects of estrogen on targeted cancer therapy drugs |
| title_sort | effects of estrogen on targeted cancer therapy drugs |
| topic | Estrogen Anticancer drugs Estrogen receptors Metabolism Precision therapy Resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1043661822000767 |
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