Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions
Background: Sepsis is the leading cause of mortality in intensive care units (ICUs). However, early diagnosis and prognosis of sepsis and septic shock are still a great challenge. Pentraxin-3 (PTX3) was shown to be associated with the severity and outcome of sepsis and septic shock. This study was c...
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MDPI AG
2021-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/10/1906 |
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| author | Huan Chen Tao Li Shanshan Yan Meidong Liu Ke Liu Huali Zhang Min Gao Xianzhong Xiao |
| author_facet | Huan Chen Tao Li Shanshan Yan Meidong Liu Ke Liu Huali Zhang Min Gao Xianzhong Xiao |
| author_sort | Huan Chen |
| collection | DOAJ |
| description | Background: Sepsis is the leading cause of mortality in intensive care units (ICUs). However, early diagnosis and prognosis of sepsis and septic shock are still a great challenge. Pentraxin-3 (PTX3) was shown to be associated with the severity and outcome of sepsis and septic shock. This study was carried out to investigate the diagnostic and prognostic value of PTX3 in patients with sepsis and septic shock based on Sepsis 3.0 definitions. Methods: In this single-center prospective observational study, all patients’ serum was collected for biomarker measurements within 24 h after admission. Logistic and Cox regression analyses were used to identify the potential biomarkers of diagnosis, severity stratification, and prediction. Results: Serum levels of PTX3 were significantly increased on the first day of ICU admission, while septic shock patients had highest PTX3 levels than other groups. A combination between PTX3 and procalcitonin (PCT) could better discriminate sepsis and septic shock, and PTX3 was an independent predictor of mortality in sepsis and septic shock patients. Conclusion: PTX3 may be a robust biomarker to classify the disease severity and predict the 90-day mortality of sepsis and septic shock based on the latest Sepsis 3.0 definitions. |
| first_indexed | 2024-03-10T06:38:02Z |
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| id | doaj.art-dfd6611407504686a9937200aa0c1842 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T06:38:02Z |
| publishDate | 2021-10-01 |
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| series | Diagnostics |
| spelling | doaj.art-dfd6611407504686a9937200aa0c18422023-11-22T17:58:36ZengMDPI AGDiagnostics2075-44182021-10-011110190610.3390/diagnostics11101906Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 DefinitionsHuan Chen0Tao Li1Shanshan Yan2Meidong Liu3Ke Liu4Huali Zhang5Min Gao6Xianzhong Xiao7Postdoctoral Research Station of Clinical Medicine & Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Pathophysiology, Medical College of Jiaying University, Meizhou 514031, ChinaDepartment of Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaSepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha 410078, ChinaSepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha 410078, ChinaSepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha 410078, ChinaDepartment of Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaSepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha 410078, ChinaBackground: Sepsis is the leading cause of mortality in intensive care units (ICUs). However, early diagnosis and prognosis of sepsis and septic shock are still a great challenge. Pentraxin-3 (PTX3) was shown to be associated with the severity and outcome of sepsis and septic shock. This study was carried out to investigate the diagnostic and prognostic value of PTX3 in patients with sepsis and septic shock based on Sepsis 3.0 definitions. Methods: In this single-center prospective observational study, all patients’ serum was collected for biomarker measurements within 24 h after admission. Logistic and Cox regression analyses were used to identify the potential biomarkers of diagnosis, severity stratification, and prediction. Results: Serum levels of PTX3 were significantly increased on the first day of ICU admission, while septic shock patients had highest PTX3 levels than other groups. A combination between PTX3 and procalcitonin (PCT) could better discriminate sepsis and septic shock, and PTX3 was an independent predictor of mortality in sepsis and septic shock patients. Conclusion: PTX3 may be a robust biomarker to classify the disease severity and predict the 90-day mortality of sepsis and septic shock based on the latest Sepsis 3.0 definitions.https://www.mdpi.com/2075-4418/11/10/1906pentraxin-3sepsisseptic shockbiomarkerprognosisintensive care units |
| spellingShingle | Huan Chen Tao Li Shanshan Yan Meidong Liu Ke Liu Huali Zhang Min Gao Xianzhong Xiao Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions Diagnostics pentraxin-3 sepsis septic shock biomarker prognosis intensive care units |
| title | Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions |
| title_full | Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions |
| title_fullStr | Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions |
| title_full_unstemmed | Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions |
| title_short | Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions |
| title_sort | pentraxin 3 is a strong biomarker of sepsis severity identification and predictor of 90 day mortality in intensive care units via sepsis 3 0 definitions |
| topic | pentraxin-3 sepsis septic shock biomarker prognosis intensive care units |
| url | https://www.mdpi.com/2075-4418/11/10/1906 |
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