Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals
Summary: The purpose of this study was to analyze molecular docking as a search for aglycone isoflavone in TGF-β, Hsp70, and apoptosis pathways that are useful for pelvic organ prolapse treatment. This in silico study involved procedures of searching for protein and nucleotide sequences, three-dimen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-02-01
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| Series: | Clinical Nutrition Experimental |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352939318300204 |
| _version_ | 1811254576460857344 |
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| author | Pribakti Budinurdjaja I Wayan Arsana Wiyasa Ika Kustiyah Oktaviyanti Djanggan Sargowo |
| author_facet | Pribakti Budinurdjaja I Wayan Arsana Wiyasa Ika Kustiyah Oktaviyanti Djanggan Sargowo |
| author_sort | Pribakti Budinurdjaja |
| collection | DOAJ |
| description | Summary: The purpose of this study was to analyze molecular docking as a search for aglycone isoflavone in TGF-β, Hsp70, and apoptosis pathways that are useful for pelvic organ prolapse treatment. This in silico study involved procedures of searching for protein and nucleotide sequences, three-dimensional structure modeling, docking, and interaction analysis. Against TGF-β signal, the genistein facilitated interaction between TGF-β and TGF-β receptor, while against Hsp70 signal, the daidzein facilitated interaction of HSF and Hsp70. Against NF-κB signal for Bcl-xl gene, daidzein and glycitein facilitated interaction of NF-κB and Bcl-xl gene. It was concluded that aglycone isoflavone of the soybean could modulate TGF-β1, Hsp70, and Bcl-xl anti-apoptotic signals. Therefore, aglycone isoflavone derived from soybean can become an alternative nutrient or candidate for herbal product for pelvic organ prolapse treatment. Keywords: Daidzein, Genistein, Glycitein, In silico |
| first_indexed | 2024-04-12T17:09:37Z |
| format | Article |
| id | doaj.art-dfd6b80105f844bf9b1b29f3ec5088f4 |
| institution | Directory Open Access Journal |
| issn | 2352-9393 |
| language | English |
| last_indexed | 2024-04-12T17:09:37Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Experimental |
| spelling | doaj.art-dfd6b80105f844bf9b1b29f3ec5088f42022-12-22T03:23:50ZengElsevierClinical Nutrition Experimental2352-93932019-02-01231522Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signalsPribakti Budinurdjaja0I Wayan Arsana Wiyasa1Ika Kustiyah Oktaviyanti2Djanggan Sargowo3Doctoral Program in Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia; Department of Obstetric and Gynecology, Faculty of Medicine Universitas Lambung Mangkurat/Ulin General Hospital, Banjarmasin, South Kalimantan, Indonesia; Corresponding author. Doctoral Program in Medicine, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran, Malang, East Java, Indonesia.Department of Obstetric and Gynecology, Faculty of Medicine Universitas Brawijaya/dr. Saiful Anwar General Hospital, Malang, East Java, IndonesiaDepartment of Pathology, Faculty of Medicine Universitas Lambung Mangkurat/Ulin General Hospital, Banjarmasin, South Kalimantan, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Brawijaya/dr. Saiful Anwar General Hospital, Malang, East Java, IndonesiaSummary: The purpose of this study was to analyze molecular docking as a search for aglycone isoflavone in TGF-β, Hsp70, and apoptosis pathways that are useful for pelvic organ prolapse treatment. This in silico study involved procedures of searching for protein and nucleotide sequences, three-dimensional structure modeling, docking, and interaction analysis. Against TGF-β signal, the genistein facilitated interaction between TGF-β and TGF-β receptor, while against Hsp70 signal, the daidzein facilitated interaction of HSF and Hsp70. Against NF-κB signal for Bcl-xl gene, daidzein and glycitein facilitated interaction of NF-κB and Bcl-xl gene. It was concluded that aglycone isoflavone of the soybean could modulate TGF-β1, Hsp70, and Bcl-xl anti-apoptotic signals. Therefore, aglycone isoflavone derived from soybean can become an alternative nutrient or candidate for herbal product for pelvic organ prolapse treatment. Keywords: Daidzein, Genistein, Glycitein, In silicohttp://www.sciencedirect.com/science/article/pii/S2352939318300204 |
| spellingShingle | Pribakti Budinurdjaja I Wayan Arsana Wiyasa Ika Kustiyah Oktaviyanti Djanggan Sargowo Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals Clinical Nutrition Experimental |
| title | Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals |
| title_full | Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals |
| title_fullStr | Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals |
| title_full_unstemmed | Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals |
| title_short | Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals |
| title_sort | search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment in silico study of tgf β1 hsp70 and bcl xl signals |
| url | http://www.sciencedirect.com/science/article/pii/S2352939318300204 |
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