The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex

The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex

Introduction:. Chronic pain is associated with persistent but reversible structural and functional changes in the prefrontal cortex (PFC). This stable yet malleable plasticity implicates epigenetic mechanisms, including DNA methylation, as a potential mediator of chronic pain–induced cortical pathol...

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Bibliographic Details
Main Authors:	Lucas Topham, Stephanie Gregoire, HyungMo Kang, Mali Salmon-Divon, Elad Lax, Magali Millecamps, Moshe Szyf, Laura Stone
Format:	Article
Language:	English
Published:	Wolters Kluwer 2021-08-01
Series:	PAIN Reports
Online Access:	http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000944

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