The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation
Abstract In human female primordial germ cells, the transition from mitosis to meiosis begins from the fetal stage. In germ cells, meiosis is arrested at the diplotene stage of prophase in meiosis I (MI) after synapsis and recombination of homologous chromosomes, which cannot be segregated. Within t...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-023-01143-0 |
| _version_ | 1797451078954909696 |
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| author | Zhenle Pei Ke Deng Congjian Xu Shuo Zhang |
| author_facet | Zhenle Pei Ke Deng Congjian Xu Shuo Zhang |
| author_sort | Zhenle Pei |
| collection | DOAJ |
| description | Abstract In human female primordial germ cells, the transition from mitosis to meiosis begins from the fetal stage. In germ cells, meiosis is arrested at the diplotene stage of prophase in meiosis I (MI) after synapsis and recombination of homologous chromosomes, which cannot be segregated. Within the follicle, the maintenance of oocyte meiotic arrest is primarily attributed to high cytoplasmic concentrations of cyclic adenosine monophosphate (cAMP). Depending on the specific species, oocytes can remain arrested for extended periods of time, ranging from months to even years. During estrus phase in animals or the menstrual cycle in humans, the resumption of meiosis occurs in certain oocytes due to a surge of luteinizing hormone (LH) levels. Any factor interfering with this process may lead to impaired oocyte maturation, which in turn affects female reproductive function. Nevertheless, the precise molecular mechanisms underlying this phenomenon has not been systematically summarized yet. To provide a comprehensive understanding of the recently uncovered regulatory network involved in oocyte development and maturation, the progress of the cellular and molecular mechanisms of oocyte nuclear maturation including meiosis arrest and meiosis resumption is summarized. Additionally, the advancements in understanding the molecular cytoplasmic events occurring in oocytes, such as maternal mRNA degradation, posttranslational regulation, and organelle distribution associated with the quality of oocyte maturation, are reviewed. Therefore, understanding the pathways regulating oocyte meiotic arrest and resumption will provide detailed insight into female reproductive system and provide a theoretical basis for further research and potential approaches for novel disease treatments. |
| first_indexed | 2024-03-09T14:48:47Z |
| format | Article |
| id | doaj.art-dfd748cf15d948a0bd4c8743ac633952 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-03-09T14:48:47Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-dfd748cf15d948a0bd4c8743ac6339522023-11-26T14:35:33ZengBMCReproductive Biology and Endocrinology1477-78272023-10-0121111210.1186/s12958-023-01143-0The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturationZhenle Pei0Ke Deng1Congjian Xu2Shuo Zhang3Shanghai Ji Ai Genetics & IVF Institute, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan UniversityShanghai Ji Ai Genetics & IVF Institute, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan UniversityShanghai Ji Ai Genetics & IVF Institute, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan UniversityShanghai Ji Ai Genetics & IVF Institute, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan UniversityAbstract In human female primordial germ cells, the transition from mitosis to meiosis begins from the fetal stage. In germ cells, meiosis is arrested at the diplotene stage of prophase in meiosis I (MI) after synapsis and recombination of homologous chromosomes, which cannot be segregated. Within the follicle, the maintenance of oocyte meiotic arrest is primarily attributed to high cytoplasmic concentrations of cyclic adenosine monophosphate (cAMP). Depending on the specific species, oocytes can remain arrested for extended periods of time, ranging from months to even years. During estrus phase in animals or the menstrual cycle in humans, the resumption of meiosis occurs in certain oocytes due to a surge of luteinizing hormone (LH) levels. Any factor interfering with this process may lead to impaired oocyte maturation, which in turn affects female reproductive function. Nevertheless, the precise molecular mechanisms underlying this phenomenon has not been systematically summarized yet. To provide a comprehensive understanding of the recently uncovered regulatory network involved in oocyte development and maturation, the progress of the cellular and molecular mechanisms of oocyte nuclear maturation including meiosis arrest and meiosis resumption is summarized. Additionally, the advancements in understanding the molecular cytoplasmic events occurring in oocytes, such as maternal mRNA degradation, posttranslational regulation, and organelle distribution associated with the quality of oocyte maturation, are reviewed. Therefore, understanding the pathways regulating oocyte meiotic arrest and resumption will provide detailed insight into female reproductive system and provide a theoretical basis for further research and potential approaches for novel disease treatments.https://doi.org/10.1186/s12958-023-01143-0OocyteMeiotic arrestMeiotic resumptioncAMPcGMP |
| spellingShingle | Zhenle Pei Ke Deng Congjian Xu Shuo Zhang The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation Reproductive Biology and Endocrinology Oocyte Meiotic arrest Meiotic resumption cAMP cGMP |
| title | The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation |
| title_full | The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation |
| title_fullStr | The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation |
| title_full_unstemmed | The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation |
| title_short | The molecular regulatory mechanisms of meiotic arrest and resumption in Oocyte development and maturation |
| title_sort | molecular regulatory mechanisms of meiotic arrest and resumption in oocyte development and maturation |
| topic | Oocyte Meiotic arrest Meiotic resumption cAMP cGMP |
| url | https://doi.org/10.1186/s12958-023-01143-0 |
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