Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk
Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs, that can be transferred to infants and it plays on a critical role in biological functions such as immune regulation and development. However, the origin and fu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Animal Sciences and Technology
2021-05-01
|
| Series: | Journal of Animal Science and Technology |
| Subjects: | |
| Online Access: | http://www.ejast.org/archive/view_article?pid=jast-63-3-593 |
| Summary: | Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs,
that can be transferred to infants and it plays on a critical role in biological
functions such as immune regulation and development. However, the origin and
functional importance of milk-derived miRNAs are still undetermined. This study
applied RNA sequencing to explore the featured profiles of miRNA expression in
colostrum and mature milk-originated exosomes from human, bovine, and caprine
milk. These dietary exosome-derived miRNAs are highly conserved in human, bovine
and caprine milk. Interestingly, abundant miRNAs expressed in human milk are
similarly conserved across species. In addition, we confirmed that
immune-related miRNAs (miR-30a-5p, miR-22-3p, and miR-26a) are commonly observed
in the colostrum and mature milk of cows and caprines as well as humans. Our
results provide new insights and resources for investigating the functionality
of immune-associated miRNAs and evaluating physiological and biological
condition in human, bovine and caprine milk as biomarkers. |
|---|---|
| ISSN: | 2672-0191 2055-0391 |