Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk
Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs, that can be transferred to infants and it plays on a critical role in biological functions such as immune regulation and development. However, the origin and fu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Animal Sciences and Technology
2021-05-01
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| Series: | Journal of Animal Science and Technology |
| Subjects: | |
| Online Access: | http://www.ejast.org/archive/view_article?pid=jast-63-3-593 |
| _version_ | 1818872025703251968 |
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| author | Bohyun Yun Younghoon Kim Dong June Park Sangnam Oh |
| author_facet | Bohyun Yun Younghoon Kim Dong June Park Sangnam Oh |
| author_sort | Bohyun Yun |
| collection | DOAJ |
| description | Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs,
that can be transferred to infants and it plays on a critical role in biological
functions such as immune regulation and development. However, the origin and
functional importance of milk-derived miRNAs are still undetermined. This study
applied RNA sequencing to explore the featured profiles of miRNA expression in
colostrum and mature milk-originated exosomes from human, bovine, and caprine
milk. These dietary exosome-derived miRNAs are highly conserved in human, bovine
and caprine milk. Interestingly, abundant miRNAs expressed in human milk are
similarly conserved across species. In addition, we confirmed that
immune-related miRNAs (miR-30a-5p, miR-22-3p, and miR-26a) are commonly observed
in the colostrum and mature milk of cows and caprines as well as humans. Our
results provide new insights and resources for investigating the functionality
of immune-associated miRNAs and evaluating physiological and biological
condition in human, bovine and caprine milk as biomarkers. |
| first_indexed | 2024-12-19T12:32:15Z |
| format | Article |
| id | doaj.art-dfd971cdc1fb4667af3fd4f1e64a4b58 |
| institution | Directory Open Access Journal |
| issn | 2672-0191 2055-0391 |
| language | English |
| last_indexed | 2024-12-19T12:32:15Z |
| publishDate | 2021-05-01 |
| publisher | Korean Society of Animal Sciences and Technology |
| record_format | Article |
| series | Journal of Animal Science and Technology |
| spelling | doaj.art-dfd971cdc1fb4667af3fd4f1e64a4b582022-12-21T20:21:16ZengKorean Society of Animal Sciences and TechnologyJournal of Animal Science and Technology2672-01912055-03912021-05-0163359360210.5187/jast.2021.e39jast-63-3-593Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milkBohyun Yun0Younghoon Kim1Dong June Park2Sangnam Oh3Department of Functional Food and Biotechnology, Jeonju University, Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Korea Food Research Institute, Department of Functional Food and Biotechnology, Jeonju University, Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs, that can be transferred to infants and it plays on a critical role in biological functions such as immune regulation and development. However, the origin and functional importance of milk-derived miRNAs are still undetermined. This study applied RNA sequencing to explore the featured profiles of miRNA expression in colostrum and mature milk-originated exosomes from human, bovine, and caprine milk. These dietary exosome-derived miRNAs are highly conserved in human, bovine and caprine milk. Interestingly, abundant miRNAs expressed in human milk are similarly conserved across species. In addition, we confirmed that immune-related miRNAs (miR-30a-5p, miR-22-3p, and miR-26a) are commonly observed in the colostrum and mature milk of cows and caprines as well as humans. Our results provide new insights and resources for investigating the functionality of immune-associated miRNAs and evaluating physiological and biological condition in human, bovine and caprine milk as biomarkers.http://www.ejast.org/archive/view_article?pid=jast-63-3-593colostrummature milkdietary exosomemicrornamammals |
| spellingShingle | Bohyun Yun Younghoon Kim Dong June Park Sangnam Oh Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk Journal of Animal Science and Technology colostrum mature milk dietary exosome microrna mammals |
| title | Comparative analysis of dietary exosome-derived microRNAs from human,
bovine and caprine colostrum and mature milk |
| title_full | Comparative analysis of dietary exosome-derived microRNAs from human,
bovine and caprine colostrum and mature milk |
| title_fullStr | Comparative analysis of dietary exosome-derived microRNAs from human,
bovine and caprine colostrum and mature milk |
| title_full_unstemmed | Comparative analysis of dietary exosome-derived microRNAs from human,
bovine and caprine colostrum and mature milk |
| title_short | Comparative analysis of dietary exosome-derived microRNAs from human,
bovine and caprine colostrum and mature milk |
| title_sort | comparative analysis of dietary exosome derived micrornas from human bovine and caprine colostrum and mature milk |
| topic | colostrum mature milk dietary exosome microrna mammals |
| url | http://www.ejast.org/archive/view_article?pid=jast-63-3-593 |
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