Bv8 Blockade Sensitizes Anti-PD1 Therapy Resistant Tumors

Bv8 Blockade Sensitizes Anti-PD1 Therapy Resistant Tumors

Myeloid-derived suppressor cells (MDSCs) are known to promote tumor growth in part by their immunosuppressive activities and their angiogenesis support. It has been shown that Bv8 blockade inhibits the recruitment of MDSCs to tumors, thereby delaying tumor relapse associated with resistance to antia...

Full description

Bibliographic Details
Main Authors:	Madeleine Benguigui, Avital Vorontsova, Michael Timaner, Sapir Levin, Jozafina Haj-Shomaly, Abhilash Deo, Rotem Menachem, Bar Manobla, Tim J. Cooper, Ziv Raviv, Yuval Shaked
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Immunology
Subjects:	immunotherapy MDSC resistance Bv8 tumor microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.903591/full

Similar Items

The Dichotomous Role of Bone Marrow Derived Cells in the Chemotherapy-Treated Tumor Microenvironment
by: Avital Vorontsova, et al.
Published: (2020-12-01)

CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development
by: Elias Hawila, et al.
Published: (2017-11-01)

Anti-Bv8 Antibody and Metronomic Gemcitabine Improve Pancreatic Adenocarcinoma Treatment Outcome Following Weekly Gemcitabine Therapy
by: Erez Hasnis, et al.
Published: (2014-06-01)

Host response to immune checkpoint inhibitors contributes to tumor aggressiveness
by: Ziv Raviv, et al.
Published: (2021-03-01)

The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study
by: Tal Goshen-Lago, et al.
Published: (2020-08-01)

Effect of Immune Checkpoint Blockade on Myeloid-Derived Suppressor Cell Populations in Patients With Melanoma
by: Steven H. Sun, et al.
Published: (2021-10-01)

CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy
by: Ayush Pant, et al.
Published: (2024-12-01)

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival
by: Rostislav Novak, et al.
Published: (2022-09-01)

De novo transcriptome characterization of Iris atropurpurea (the Royal Iris) and phylogenetic analysis of MADS-box and R2R3-MYB gene families
by: Bar-Lev Yamit, et al.
Published: (2021-08-01)

Author Correction: De novo transcriptome characterization of Iris atropurpurea (the Royal Iris) and phylogenetic analysis of MADS-box and R2R3-MYB gene families
by: Yamit Bar-Lev, et al.
Published: (2021-09-01)

Neutrophil Heterogeneity in Cancer: From Biology to Therapies
by: Pacôme Lecot, et al.
Published: (2019-09-01)

Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer
by: Maryna Bondarenko, et al.
Published: (2021-05-01)

Tumor Cell-Associated IL-1α Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment
by: Mathumathi Krishnamohan, et al.
Published: (2024-04-01)

PDX Models: A Versatile Tool for Studying the Role of Myeloid-Derived Suppressor Cells in Breast Cancer
by: Morten F. Gjerstorff, et al.
Published: (2022-12-01)

Myeloid-Derived Suppressor Cells in COVID-19: The Paradox of Good
by: Germana Grassi, et al.
Published: (2022-04-01)

Myeloid-derived suppressor cells in Chronic myeloid leukemia
by: Cesarina eGiallongo, et al.
Published: (2015-05-01)

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3
by: Dror Alishekevitz, et al.
Published: (2016-10-01)

DNA methylation in the promoters of PD-L1, MMP9, ARG1, galectin-9, TIM-3, VISTA and TGF-β genes in HLA-DR– myeloid cells, compared with HLA-DR+ antigen-presenting cells
by: Reem Saleh, et al.
Published: (2020-12-01)

Myeloid-Derived Suppressor Cells: A Multifaceted Accomplice in Tumor Progression
by: Jia-Nan Cheng, et al.
Published: (2021-12-01)

HIF-1α-Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice
by: Natascha Köstlin-Gille, et al.
Published: (2019-02-01)

To Produce or to Survive: How Plastic Is Your Crop Stress Physiology?
by: Ahan Dalal, et al.
Published: (2017-12-01)

Tissue contexture determines the pattern and density of tumor-infiltrating immune cells in HPV-associated squamous cell carcinomas of oropharynx and uterine cervix
by: Lucie Pavelková, et al.
Published: (2024-03-01)

Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases
by: Chen Rachman-Tzemah, et al.
Published: (2017-04-01)

Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.
by: Tatyana Kushnir, et al.
Published: (2017-06-01)

T<sub>h</sub>17, T<sub>h</sub>22, and Myeloid-Derived Suppressor Cell Population Dynamics and Response to IL-6 in 4T1 Mammary Carcinoma
by: Viva J. Rasé, et al.
Published: (2022-09-01)

Parental Regret Following Decision to Revise Circumcision
by: Noam Bar-Yaakov, et al.
Published: (2022-03-01)

Spleen-Derived CCL9 Recruits MDSC to Facilitate Tumor Growth in Orthotopic Hepatoma Mice
by: Baohua Li, et al.
Published: (2023-12-01)

Dysregulated Immunity and Immunotherapy after Sepsis
by: Dijoia B. Darden, et al.
Published: (2021-04-01)

Depletion of Ly6G-Expressing Neutrophilic Cells Leads to Altered Peripheral T-Cell Homeostasis and Thymic Development in Neonatal Mice
by: Jessica Rühle, et al.
Published: (2023-04-01)

Depleting Ly6G Positive Myeloid Cells Reduces Pancreatic Cancer-Induced Skeletal Muscle Atrophy
by: Michael R. Deyhle, et al.
Published: (2022-06-01)

Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection
by: Alessandra Sacchi, et al.
Published: (2021-08-01)

Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions
by: Wurood Hantoosh Neamah, et al.
Published: (2023-11-01)

Myeloid-Derived Suppressor Cells (MDSC) in Melanoma Patients Treated with Anti-PD-1 Immunotherapy
by: Katarzyna Tomela, et al.
Published: (2023-03-01)

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model
by: Izzat A. M. Al-Rayahi, et al.
Published: (2021-01-01)

Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
by: Leo Leonardo, et al.
Published: (2022-09-01)

Immunotherapeutic Potential of Oncolytic Vaccinia Virus
by: Stephen eThorne
Published: (2014-06-01)

Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy
by: Serena Zilio, et al.
Published: (2016-09-01)

Clinical impact of the immunome in lymphoid malignancies: the role of Myeloid-Derived Suppressor Cells
by: Calogero eVetro, et al.
Published: (2015-05-01)

Targeted regulation of tumor microenvironment through the inhibition of MDSCs by curcumin loaded self-assembled nano-filaments
by: Tingting Wang, et al.
Published: (2022-06-01)

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
by: Chiel van Geffen, et al.
Published: (2022-08-01)