WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES
Intracranial hemorrhage (IH) is a major problem of neonatal intensive care. The incidence of IH is typically asymptomatic and cannot be effectively detected by standard diagnostic methods. The mechanisms underlying IH are unknown but there is evidence that stress-induced disorders in adrenergic regu...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2014-01-01
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| Series: | Journal of Innovative Optical Health Sciences |
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| Online Access: | http://www.worldscientific.com/doi/pdf/10.1142/S1793545813500557 |
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| author | ALEXEY N. PAVLOV ALEXEY I. NAZIMOV OLGA N. PAVLOVA VLADISLAV V. LYCHAGOV VALERY V. TUCHIN OLGA A. BIBIKOVA SERGEY S. SINDEEV OXANA V. SEMYACHKINA-GLUSHKOVSKAYA |
| author_facet | ALEXEY N. PAVLOV ALEXEY I. NAZIMOV OLGA N. PAVLOVA VLADISLAV V. LYCHAGOV VALERY V. TUCHIN OLGA A. BIBIKOVA SERGEY S. SINDEEV OXANA V. SEMYACHKINA-GLUSHKOVSKAYA |
| author_sort | ALEXEY N. PAVLOV |
| collection | DOAJ |
| description | Intracranial hemorrhage (IH) is a major problem of neonatal intensive care. The incidence of IH is typically asymptomatic and cannot be effectively detected by standard diagnostic methods. The mechanisms underlying IH are unknown but there is evidence that stress-induced disorders in adrenergic regulation of cerebral venous blood flow (CVBF) are among the main reasons. Quantitative and qualitative assessment of CVBF could significantly advance understanding of the nature of IH in newborns. In this work, we analyze variations of CVBF in newborn rats with an experimental model of stress-induced IH and adrenaline injection. Our analysis is based on the Doppler optical coherence tomography (DOCT) and a proposed adaptive wavelet-based approach that provides sensitive markers of abnormal reactions of the sagittal vein to external factors. The obtained results demonstrate that the incidence of IH in newborn rats is accompanied by a suppression of CVBF with the development of venous insufficiency and areactivity to adrenaline. We introduce a numerical measure θ, quantifying reactions of CVBF and show that the values θ < 1.23 estimated in the low-frequency (LF) spectral range corresponding to the sympathicus indicate abnormal reactions associated with the development of IH. We conclude that the revealed areactivity of the cerebral veins to adrenaline represents a possible mechanism responsible for pathological changes in CVBF. |
| first_indexed | 2024-04-14T05:37:53Z |
| format | Article |
| id | doaj.art-dfddbeafceb643c1aeb979c0d2b84ddd |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-04-14T05:37:53Z |
| publishDate | 2014-01-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-dfddbeafceb643c1aeb979c0d2b84ddd2022-12-22T02:09:35ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052014-01-01711350055-11350055-1010.1142/S179354581350055710.1142/S1793545813500557WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGESALEXEY N. PAVLOV0ALEXEY I. NAZIMOV1OLGA N. PAVLOVA2VLADISLAV V. LYCHAGOV3VALERY V. TUCHIN4OLGA A. BIBIKOVA5SERGEY S. SINDEEV6OXANA V. SEMYACHKINA-GLUSHKOVSKAYA7Department of Physics, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaDepartment of Physics, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaDepartment of Physics, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaDepartment of Physics, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaDepartment of Physics, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaDepartment of Biology, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaDepartment of Biology, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaDepartment of Biology, Saratov State University, 83 Astrakhanskaya str., Saratov 410012, RussiaIntracranial hemorrhage (IH) is a major problem of neonatal intensive care. The incidence of IH is typically asymptomatic and cannot be effectively detected by standard diagnostic methods. The mechanisms underlying IH are unknown but there is evidence that stress-induced disorders in adrenergic regulation of cerebral venous blood flow (CVBF) are among the main reasons. Quantitative and qualitative assessment of CVBF could significantly advance understanding of the nature of IH in newborns. In this work, we analyze variations of CVBF in newborn rats with an experimental model of stress-induced IH and adrenaline injection. Our analysis is based on the Doppler optical coherence tomography (DOCT) and a proposed adaptive wavelet-based approach that provides sensitive markers of abnormal reactions of the sagittal vein to external factors. The obtained results demonstrate that the incidence of IH in newborn rats is accompanied by a suppression of CVBF with the development of venous insufficiency and areactivity to adrenaline. We introduce a numerical measure θ, quantifying reactions of CVBF and show that the values θ < 1.23 estimated in the low-frequency (LF) spectral range corresponding to the sympathicus indicate abnormal reactions associated with the development of IH. We conclude that the revealed areactivity of the cerebral veins to adrenaline represents a possible mechanism responsible for pathological changes in CVBF.http://www.worldscientific.com/doi/pdf/10.1142/S1793545813500557Brain hemorrhagesoptical coherence tomographycerebrovascular dynamicswavelet analysisstress |
| spellingShingle | ALEXEY N. PAVLOV ALEXEY I. NAZIMOV OLGA N. PAVLOVA VLADISLAV V. LYCHAGOV VALERY V. TUCHIN OLGA A. BIBIKOVA SERGEY S. SINDEEV OXANA V. SEMYACHKINA-GLUSHKOVSKAYA WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES Journal of Innovative Optical Health Sciences Brain hemorrhages optical coherence tomography cerebrovascular dynamics wavelet analysis stress |
| title | WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES |
| title_full | WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES |
| title_fullStr | WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES |
| title_full_unstemmed | WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES |
| title_short | WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES |
| title_sort | wavelet based analysis of cerebrovascular dynamics in newborn rats with intracranial hemorrhages |
| topic | Brain hemorrhages optical coherence tomography cerebrovascular dynamics wavelet analysis stress |
| url | http://www.worldscientific.com/doi/pdf/10.1142/S1793545813500557 |
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