Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy
Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acousti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2020-01-01
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| Series: | BME Frontiers |
| Online Access: | http://dx.doi.org/10.34133/2020/9853609 |
| _version_ | 1827334035157811200 |
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| author | Wei Zhang Ibrahim Oraiqat Hao Lei Paul L. Carson Issam EI Naqa Xueding Wang |
| author_facet | Wei Zhang Ibrahim Oraiqat Hao Lei Paul L. Carson Issam EI Naqa Xueding Wang |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acoustic imaging (xRAI) technology and the evaluation of its feasibility for real-time monitoring of geometric and morphological misalignments of the X-ray field with respect to the target tissue by combining xRAI with established ultrasound (US) imaging, thereby improving radiotherapy tumor eradication and limiting treatment side effects. Methods. An integrated xRAI and B-mode US dual-modality system was established based on a clinic-ready research US platform. The performance of this dual-modality imaging system was evaluated via experiments on phantoms and ex vivo and in vivo rabbit liver models. Results. This system can alternatively switch between the xRAI and the US modes, with spatial resolutions of 1.1 mm and 0.37 mm, respectively. 300 times signal averaging was required for xRAI to reach a satisfactory signal-to-noise ratio, and a frame rate of 1.1 Hz was achieved with a clinical linear accelerator. The US imaging frame rate was 22 Hz, which is sufficient for real-time monitoring of the displacement of the target due to internal body motion. Conclusion. Our developed xRAI, in combination with US imaging, allows for mapping of the dose deposition in biological samples in vivo, in real-time, during radiotherapy. Impact Statement. The US-based image-guided radiotherapy system presented in this work holds great potential for personalized cancer treatment and better outcomes. |
| first_indexed | 2024-03-07T17:45:22Z |
| format | Article |
| id | doaj.art-dfddbffecff445f4b4f2f76390d2f5cc |
| institution | Directory Open Access Journal |
| issn | 2765-8031 |
| language | English |
| last_indexed | 2024-03-07T17:45:22Z |
| publishDate | 2020-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | BME Frontiers |
| spelling | doaj.art-dfddbffecff445f4b4f2f76390d2f5cc2024-03-02T15:19:07ZengAmerican Association for the Advancement of Science (AAAS)BME Frontiers2765-80312020-01-01202010.34133/2020/9853609Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of RadiotherapyWei Zhang0Ibrahim Oraiqat1Hao Lei2Paul L. Carson3Issam EI Naqa4Xueding Wang5Department of Biomedical Engineering, University of Michigan, USADepartment of Radiation Oncology, University of Michigan, USADepartment of Mechanical Engineering, University of Michigan, USADepartment of Biomedical Engineering, University of Michigan, USA; Department of Radiology, University of Michigan, USADepartment of Radiation Oncology, University of Michigan, USADepartment of Biomedical Engineering, University of Michigan, USA; Department of Radiology, University of Michigan, USAObjective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acoustic imaging (xRAI) technology and the evaluation of its feasibility for real-time monitoring of geometric and morphological misalignments of the X-ray field with respect to the target tissue by combining xRAI with established ultrasound (US) imaging, thereby improving radiotherapy tumor eradication and limiting treatment side effects. Methods. An integrated xRAI and B-mode US dual-modality system was established based on a clinic-ready research US platform. The performance of this dual-modality imaging system was evaluated via experiments on phantoms and ex vivo and in vivo rabbit liver models. Results. This system can alternatively switch between the xRAI and the US modes, with spatial resolutions of 1.1 mm and 0.37 mm, respectively. 300 times signal averaging was required for xRAI to reach a satisfactory signal-to-noise ratio, and a frame rate of 1.1 Hz was achieved with a clinical linear accelerator. The US imaging frame rate was 22 Hz, which is sufficient for real-time monitoring of the displacement of the target due to internal body motion. Conclusion. Our developed xRAI, in combination with US imaging, allows for mapping of the dose deposition in biological samples in vivo, in real-time, during radiotherapy. Impact Statement. The US-based image-guided radiotherapy system presented in this work holds great potential for personalized cancer treatment and better outcomes.http://dx.doi.org/10.34133/2020/9853609 |
| spellingShingle | Wei Zhang Ibrahim Oraiqat Hao Lei Paul L. Carson Issam EI Naqa Xueding Wang Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy BME Frontiers |
| title | Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy |
| title_full | Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy |
| title_fullStr | Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy |
| title_full_unstemmed | Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy |
| title_short | Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy |
| title_sort | dual modality x ray induced radiation acoustic and ultrasound imaging for real time monitoring of radiotherapy |
| url | http://dx.doi.org/10.34133/2020/9853609 |
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