Kleine-Levin syndrome: Etiology, diagnosis, and treatment
Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. Each episode is of brief duration varying from a week to 1-2 months an...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2010;volume=13;issue=4;spage=241;epage=246;aulast=Ramdurg |
| _version_ | 1819238690437726208 |
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| author | Ramdurg Santosh |
| author_facet | Ramdurg Santosh |
| author_sort | Ramdurg Santosh |
| collection | DOAJ |
| description | Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. Each episode is of brief duration varying from a week to 1-2 months and affected people are entirely asymptomatic between episodes. No definite cause has been identified, and no effective treatments are available even though illness is having well-defined clinical features. Multiple relapses occur every few weeks or months, and the condition may last for a decade or more before spontaneous resolution. In this study, PubMed was searched and appropriate articles were reviewed to highlight etiology, clinical features, and management of KLS. On the basis of this knowledge, practical information is offered to help clinicians about how to investigate a case of KLS, and what are the possible treatment modalities available currently for the treatment during an episode and interepisodic period for prophylaxis. Comprehensive research into the etiology, pathophysiology, investigation, and treatments are required to aid the development of disease-specific targeted therapies. |
| first_indexed | 2024-12-23T13:40:14Z |
| format | Article |
| id | doaj.art-dfddcb0ab88a4620aff2b404ab021695 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-23T13:40:14Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-dfddcb0ab88a4620aff2b404ab0216952022-12-21T17:44:53ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492010-01-01134241246Kleine-Levin syndrome: Etiology, diagnosis, and treatmentRamdurg SantoshKleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. Each episode is of brief duration varying from a week to 1-2 months and affected people are entirely asymptomatic between episodes. No definite cause has been identified, and no effective treatments are available even though illness is having well-defined clinical features. Multiple relapses occur every few weeks or months, and the condition may last for a decade or more before spontaneous resolution. In this study, PubMed was searched and appropriate articles were reviewed to highlight etiology, clinical features, and management of KLS. On the basis of this knowledge, practical information is offered to help clinicians about how to investigate a case of KLS, and what are the possible treatment modalities available currently for the treatment during an episode and interepisodic period for prophylaxis. Comprehensive research into the etiology, pathophysiology, investigation, and treatments are required to aid the development of disease-specific targeted therapies.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2010;volume=13;issue=4;spage=241;epage=246;aulast=RamdurgHypersomniahypersexualityKleine-Levin syndromemegaphagiaperiodic |
| spellingShingle | Ramdurg Santosh Kleine-Levin syndrome: Etiology, diagnosis, and treatment Annals of Indian Academy of Neurology Hypersomnia hypersexuality Kleine-Levin syndrome megaphagia periodic |
| title | Kleine-Levin syndrome: Etiology, diagnosis, and treatment |
| title_full | Kleine-Levin syndrome: Etiology, diagnosis, and treatment |
| title_fullStr | Kleine-Levin syndrome: Etiology, diagnosis, and treatment |
| title_full_unstemmed | Kleine-Levin syndrome: Etiology, diagnosis, and treatment |
| title_short | Kleine-Levin syndrome: Etiology, diagnosis, and treatment |
| title_sort | kleine levin syndrome etiology diagnosis and treatment |
| topic | Hypersomnia hypersexuality Kleine-Levin syndrome megaphagia periodic |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2010;volume=13;issue=4;spage=241;epage=246;aulast=Ramdurg |
| work_keys_str_mv | AT ramdurgsantosh kleinelevinsyndromeetiologydiagnosisandtreatment |