Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis
Purpose OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment. Methods A systematic literature review was performed to identify all p...
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2017-03-01
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| Series: | International Neurourology Journal |
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| Online Access: | http://www.einj.org/upload/pdf/inj-1732646-323.pdf |
| _version_ | 1818250310993313792 |
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| author | Hejia Yuan Yuanshan Cui Jitao Wu Peng Peng Xujie Sun Zhenli Gao |
| author_facet | Hejia Yuan Yuanshan Cui Jitao Wu Peng Peng Xujie Sun Zhenli Gao |
| author_sort | Hejia Yuan |
| collection | DOAJ |
| description | Purpose OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment. Methods A systematic literature review was performed to identify all published randomized double-blind, placebo-controlled trials of onabotulinumtoxinA for neurogenic detrusor overactivity treatment. MEDLINE, Embase, and the CENTRAL were employed. Reference lists of retrieved studies were reviewed carefully. Results Six publications involving 871 patients, which compared onabotulinumtoxinA with a placebo were analyzed. Efficacy of onabotulinumtoxinA treatment was shown as a reduction of the mean number of urinary incontinence episodes per day (mean difference, -1.41; 95% confidence interval [CI], -1.70 to -1.12; P<0.00001), maximum cystometric capacity (135.48; 95% CI, 118.22–152.75; P<0.00001), and maximum detrusor pressure (-32.98; 95% CI, -37.33 to -28.62; P<0.00001). Assessment of adverse events revealed that complications due to onabotulinumtoxinA injection were localized primarily to the urinary tract. Conclusions This meta-analysis suggests that onabotulinumtoxinA is an effective treatment for neurogenic detrusor overactivity with localized advent events. |
| first_indexed | 2024-12-12T15:50:22Z |
| format | Article |
| id | doaj.art-dfdf5cda0ac24ed9acf2d9752abe1fad |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-12T15:50:22Z |
| publishDate | 2017-03-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-dfdf5cda0ac24ed9acf2d9752abe1fad2022-12-22T00:19:39ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312017-03-01211536110.5213/inj.1732646.323648Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-AnalysisHejia Yuan0Yuanshan Cui1Jitao Wu2Peng Peng3Xujie Sun4Zhenli Gao5 Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China Department of Pathology, Affiliated Hospital of Taishan Medical University, Taian, China Department of Urology, Qingdao Chengyang People’s Hospital, Qingdao, China Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, ChinaPurpose OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment. Methods A systematic literature review was performed to identify all published randomized double-blind, placebo-controlled trials of onabotulinumtoxinA for neurogenic detrusor overactivity treatment. MEDLINE, Embase, and the CENTRAL were employed. Reference lists of retrieved studies were reviewed carefully. Results Six publications involving 871 patients, which compared onabotulinumtoxinA with a placebo were analyzed. Efficacy of onabotulinumtoxinA treatment was shown as a reduction of the mean number of urinary incontinence episodes per day (mean difference, -1.41; 95% confidence interval [CI], -1.70 to -1.12; P<0.00001), maximum cystometric capacity (135.48; 95% CI, 118.22–152.75; P<0.00001), and maximum detrusor pressure (-32.98; 95% CI, -37.33 to -28.62; P<0.00001). Assessment of adverse events revealed that complications due to onabotulinumtoxinA injection were localized primarily to the urinary tract. Conclusions This meta-analysis suggests that onabotulinumtoxinA is an effective treatment for neurogenic detrusor overactivity with localized advent events.http://www.einj.org/upload/pdf/inj-1732646-323.pdfNeurogenic Detrusor OveractivityOnabotulinumtoxinAMeta-AnalysisRandomized Controlled Trial |
| spellingShingle | Hejia Yuan Yuanshan Cui Jitao Wu Peng Peng Xujie Sun Zhenli Gao Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis International Neurourology Journal Neurogenic Detrusor Overactivity OnabotulinumtoxinA Meta-Analysis Randomized Controlled Trial |
| title | Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis |
| title_full | Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis |
| title_fullStr | Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis |
| title_full_unstemmed | Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis |
| title_short | Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis |
| title_sort | efficacy and adverse events associated with use of onabotulinumtoxina for treatment of neurogenic detrusor overactivity a meta analysis |
| topic | Neurogenic Detrusor Overactivity OnabotulinumtoxinA Meta-Analysis Randomized Controlled Trial |
| url | http://www.einj.org/upload/pdf/inj-1732646-323.pdf |
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