Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative Review
Circulating tumor DNA (ctDNA) has been investigated as a potential noninvasive biomarker for disease prognostication, monitoring, and treatment selection in various tumor types, including renal cell carcinoma (RCC). In this narrative review, we explore the current methods of ctDNA anal...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Société Internationale d’Urologie (SIU)
2023-07-01
|
| Series: | Société Internationale d’Urologie Journal |
| Subjects: | |
| Online Access: | https://siuj.org/index.php/siuj/article/view/282/232 |
| _version_ | 1797372255041224704 |
|---|---|
| author | Wesley Yip A. Ari Hakimi |
| author_facet | Wesley Yip A. Ari Hakimi |
| author_sort | Wesley Yip |
| collection | DOAJ |
| description | Circulating tumor DNA (ctDNA) has been investigated as a potential noninvasive biomarker for disease prognostication, monitoring, and treatment selection in various tumor types, including renal cell carcinoma (RCC). In this narrative review, we explore the current methods of ctDNA analysis and the use of ctDNA in both localized and metastatic RCC, focusing on plasma and urine samples. Additionally, we discuss several ongoing as well as upcoming clinical trials that incorporate ctDNA analyses into their study designs and outcomes. Despite the exciting potential of ctDNA in RCC, current assays still face significant limitations in sensitivity and detection limits. |
| first_indexed | 2024-03-08T18:33:08Z |
| format | Article |
| id | doaj.art-dfdfe6793c6a4297b00661bd4f0c63c0 |
| institution | Directory Open Access Journal |
| issn | 2563-6499 |
| language | English |
| last_indexed | 2024-03-08T18:33:08Z |
| publishDate | 2023-07-01 |
| publisher | The Société Internationale d’Urologie (SIU) |
| record_format | Article |
| series | Société Internationale d’Urologie Journal |
| spelling | doaj.art-dfdfe6793c6a4297b00661bd4f0c63c02023-12-29T23:16:17ZengThe Société Internationale d’Urologie (SIU)Société Internationale d’Urologie Journal2563-64992023-07-014428729210.48083/JESK5072Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative ReviewWesley Yip A. Ari HakimiCirculating tumor DNA (ctDNA) has been investigated as a potential noninvasive biomarker for disease prognostication, monitoring, and treatment selection in various tumor types, including renal cell carcinoma (RCC). In this narrative review, we explore the current methods of ctDNA analysis and the use of ctDNA in both localized and metastatic RCC, focusing on plasma and urine samples. Additionally, we discuss several ongoing as well as upcoming clinical trials that incorporate ctDNA analyses into their study designs and outcomes. Despite the exciting potential of ctDNA in RCC, current assays still face significant limitations in sensitivity and detection limits. https://siuj.org/index.php/siuj/article/view/282/232renal cell carcinomabiomarkersctdna |
| spellingShingle | Wesley Yip A. Ari Hakimi Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative Review Société Internationale d’Urologie Journal renal cell carcinoma biomarkers ctdna |
| title | Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative Review |
| title_full | Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative Review |
| title_fullStr | Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative Review |
| title_full_unstemmed | Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative Review |
| title_short | Circulating Tumor DNA (ctDNA) in Kidney Cancer: A Narrative Review |
| title_sort | circulating tumor dna ctdna in kidney cancer a narrative review |
| topic | renal cell carcinoma biomarkers ctdna |
| url | https://siuj.org/index.php/siuj/article/view/282/232 |
| work_keys_str_mv | AT wesleyyip circulatingtumordnactdnainkidneycanceranarrativereview AT aarihakimi circulatingtumordnactdnainkidneycanceranarrativereview |