The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study
BackgroundPrompt interventions prevent adverse events (AE) in hypertrophic cardiomyopathy (HCM). We evaluated the pattern and the predictive role of feature tracking (FT)-cardiac magnetic resonance (CMR) imaging parameters in an HCM population with a normal left ventricular ejection fraction (LVEF)...
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| Format: | Article |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1246759/full |
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| author | Alireza Salmanipour Amir Ghaffari Jolfayi Nazanin Sabet Khadem Nahid Rezaeian Hamid Chalian Saeideh Mazloomzadeh Sara Adimi Sanaz Asadian |
| author_facet | Alireza Salmanipour Amir Ghaffari Jolfayi Nazanin Sabet Khadem Nahid Rezaeian Hamid Chalian Saeideh Mazloomzadeh Sara Adimi Sanaz Asadian |
| author_sort | Alireza Salmanipour |
| collection | DOAJ |
| description | BackgroundPrompt interventions prevent adverse events (AE) in hypertrophic cardiomyopathy (HCM). We evaluated the pattern and the predictive role of feature tracking (FT)-cardiac magnetic resonance (CMR) imaging parameters in an HCM population with a normal left ventricular ejection fraction (LVEF) and a low fibrosis burden.MethodsThe CMR and clinical data of 170 patients, consisting of 142 HCM (45 ± 15.7 years, 62.7% male) and 28 healthy (42.2 ± 11.26 years, 50% male) subjects, who were enrolled from 2015 to 2020, were evaluated. HCM patients had a normal LVEF with a late gadolinium enhancement (LGE) percentage below 15%. Between-group differences were described, and the potent predictors of AE were determined. A P-value below 0.05 was considered significant.ResultsLV global longitudinal, circumferential, and radial strains (GLS, GCS, and GRS, respectively) and the LV myocardial mass index (MMI) were different between the healthy and HCM cases (all Ps < 0.05). Strains were significantly impaired in the HCM patients with a normal MMI. A progressive decrease in LVGLS and a distinct fall in LVGCS were noted with a rise in MMI. AE were predicted by LVGLS, LVGCS, and the LGE percentage, and LVGCS was the single robust predictor (HR, 1.144; 95% CI, 1.080–1.212; P = 0.001). An LVGCS below 16.2% predicted AE with 77% specificity and 58% sensitivity.ConclusionsLV strains were impaired in HCM patients with a normal EF and a low fibrosis burden, even in the presence of a normal MMI. CMR parameters, especially FT-CMR values, predicted AE in our HCM patients. |
| first_indexed | 2024-03-12T01:15:09Z |
| format | Article |
| id | doaj.art-dfe16c40c6654b7096e0ebc2cba3abe8 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T01:15:09Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-dfe16c40c6654b7096e0ebc2cba3abe82023-09-13T18:59:49ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-09-011010.3389/fcvm.2023.12467591246759The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort studyAlireza Salmanipour0Amir Ghaffari Jolfayi1Nazanin Sabet Khadem2Nahid Rezaeian3Hamid Chalian4Saeideh Mazloomzadeh5Sara Adimi6Sanaz Asadian7Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Radiology, Cardiothoracic Imaging, University of Washington, Seattle, WA, United StatesRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranBackgroundPrompt interventions prevent adverse events (AE) in hypertrophic cardiomyopathy (HCM). We evaluated the pattern and the predictive role of feature tracking (FT)-cardiac magnetic resonance (CMR) imaging parameters in an HCM population with a normal left ventricular ejection fraction (LVEF) and a low fibrosis burden.MethodsThe CMR and clinical data of 170 patients, consisting of 142 HCM (45 ± 15.7 years, 62.7% male) and 28 healthy (42.2 ± 11.26 years, 50% male) subjects, who were enrolled from 2015 to 2020, were evaluated. HCM patients had a normal LVEF with a late gadolinium enhancement (LGE) percentage below 15%. Between-group differences were described, and the potent predictors of AE were determined. A P-value below 0.05 was considered significant.ResultsLV global longitudinal, circumferential, and radial strains (GLS, GCS, and GRS, respectively) and the LV myocardial mass index (MMI) were different between the healthy and HCM cases (all Ps < 0.05). Strains were significantly impaired in the HCM patients with a normal MMI. A progressive decrease in LVGLS and a distinct fall in LVGCS were noted with a rise in MMI. AE were predicted by LVGLS, LVGCS, and the LGE percentage, and LVGCS was the single robust predictor (HR, 1.144; 95% CI, 1.080–1.212; P = 0.001). An LVGCS below 16.2% predicted AE with 77% specificity and 58% sensitivity.ConclusionsLV strains were impaired in HCM patients with a normal EF and a low fibrosis burden, even in the presence of a normal MMI. CMR parameters, especially FT-CMR values, predicted AE in our HCM patients.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1246759/fullhypertrophic cardiomyopathy (HCM)cardiac MRIfeature trackingcardiac functionadverse events |
| spellingShingle | Alireza Salmanipour Amir Ghaffari Jolfayi Nazanin Sabet Khadem Nahid Rezaeian Hamid Chalian Saeideh Mazloomzadeh Sara Adimi Sanaz Asadian The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study Frontiers in Cardiovascular Medicine hypertrophic cardiomyopathy (HCM) cardiac MRI feature tracking cardiac function adverse events |
| title | The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study |
| title_full | The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study |
| title_fullStr | The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study |
| title_full_unstemmed | The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study |
| title_short | The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study |
| title_sort | predictive value of cardiac mri strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden a retrospective cohort study |
| topic | hypertrophic cardiomyopathy (HCM) cardiac MRI feature tracking cardiac function adverse events |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1246759/full |
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