M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury

M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury

After spinal cord injury (SCI), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon regeneration. Meanwhile, microglia gradually accumulate...

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Bibliographic Details
Main Authors: Shui-Sheng Yu, Zi-Yu Li, Xin-Zhong Xu, Fei Yao, Yang Luo, Yan-Chang Liu, Li Cheng, Mei-Ge Zheng, Jue-Hua Jing
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
astrocytes; astrocytic scar; chondroitin sulfate proteoglycan; m1/m2 polarization; microglia; sex-determining region y-box 9; spinal cord injury; transforming growth factor-β1
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=5;spage=1072;epage=1079;aulast=Yu

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