Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...

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Bibliographic Details
Main Authors: Igor Mokrousov, Ivaylo Slavchev, Natalia Solovieva, Marine Dogonadze, Anna Vyazovaya, Violeta Valcheva, Aleksey Masharsky, Olesya Belopolskaya, Simeon Dimitrov, Viacheslav Zhuravlev, Isabel Portugal, João Perdigão, Georgi M. Dobrikov
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
nitrofuranyl amides
<i>mycobacterium tuberculosis</i>
spontaneous mutagenesis
whole-genome sequencing
Online Access:https://www.mdpi.com/1424-8247/15/9/1136

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