Decreased Levels of Vitamin D in Bipolar Patients
Recently, vitamin D is considered a pleiotropic hormone, and as such, it has also become a topic of renewed interest in neuropsychiatry for its proposed role in the aetiology and pathophysiology of different psychiatric conditions, including mood disorders (MDs). This seems particularly crucial whil...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/4/883 |
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| author | Donatella Marazziti Paola Mangiapane Manuel Glauco Carbone Florinda Morana Alessandro Arone Lucia Massa Stefania Palermo Miriam Violi Giovanni Bertini Leonardo Massoni Sara Fantasia Andrea Pozza Federico Mucci Benedetto Morana |
| author_facet | Donatella Marazziti Paola Mangiapane Manuel Glauco Carbone Florinda Morana Alessandro Arone Lucia Massa Stefania Palermo Miriam Violi Giovanni Bertini Leonardo Massoni Sara Fantasia Andrea Pozza Federico Mucci Benedetto Morana |
| author_sort | Donatella Marazziti |
| collection | DOAJ |
| description | Recently, vitamin D is considered a pleiotropic hormone, and as such, it has also become a topic of renewed interest in neuropsychiatry for its proposed role in the aetiology and pathophysiology of different psychiatric conditions, including mood disorders (MDs). This seems particularly crucial while considering the relatively high and often neglected prevalence of hypovitaminosis D in the general population and in specific groups, such as patients suffering from the most common type of MDs, which are major depression (MDD) and bipolar disorders (BDs). Therefore, in view of the controversial literature and findings on this topic and its potential therapeutic implications, the present study aimed at evaluating vitamin D levels in the plasma of a sample of inpatients fulfilling the DSM-5 criteria for mood episodes within BDs. The clinical picture was assessed by means of specific rating scales. The results showed that the vitamin D levels (mean ± SD, nM/L) of the bipolar patients of our sample were significantly lower (14.58 ± 11.27 nmol/L) than the normative values (>30 nmol/L). Eleven patients had sufficient values and only 4 had optimal, while 19 showed insufficient, 18 critical, and 17 severely critical levels. No differences emerged according to different socio-demographic or clinical features. In our opinion, the present findings strengthen previous research highlighting decreased vitamin D levels in bipolar patients and support the role of this pleiotropic hormone in BDs. Nevertheless, further studies should follow to corroborate the data of this preliminary study and to address the potential benefits of vitamin D supplementation in the treatment of MDs. |
| first_indexed | 2024-03-11T04:50:29Z |
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| id | doaj.art-dfe99583b0cb4e3e8611d0595687dcf5 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T04:50:29Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-dfe99583b0cb4e3e8611d0595687dcf52023-11-17T20:04:57ZengMDPI AGLife2075-17292023-03-0113488310.3390/life13040883Decreased Levels of Vitamin D in Bipolar PatientsDonatella Marazziti0Paola Mangiapane1Manuel Glauco Carbone2Florinda Morana3Alessandro Arone4Lucia Massa5Stefania Palermo6Miriam Violi7Giovanni Bertini8Leonardo Massoni9Sara Fantasia10Andrea Pozza11Federico Mucci12Benedetto Morana13Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyCasa di Cura Morana, 91025 Marsala, ItalyDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, 21100 Varese, ItalyCasa di Cura Morana, 91025 Marsala, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyCasa di Cura Morana, 91025 Marsala, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Medical Science, Surgery and Neuroscience, University of Siena, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacology, University of Siena, 53100 Siena, ItalyCasa di Cura Morana, 91025 Marsala, ItalyRecently, vitamin D is considered a pleiotropic hormone, and as such, it has also become a topic of renewed interest in neuropsychiatry for its proposed role in the aetiology and pathophysiology of different psychiatric conditions, including mood disorders (MDs). This seems particularly crucial while considering the relatively high and often neglected prevalence of hypovitaminosis D in the general population and in specific groups, such as patients suffering from the most common type of MDs, which are major depression (MDD) and bipolar disorders (BDs). Therefore, in view of the controversial literature and findings on this topic and its potential therapeutic implications, the present study aimed at evaluating vitamin D levels in the plasma of a sample of inpatients fulfilling the DSM-5 criteria for mood episodes within BDs. The clinical picture was assessed by means of specific rating scales. The results showed that the vitamin D levels (mean ± SD, nM/L) of the bipolar patients of our sample were significantly lower (14.58 ± 11.27 nmol/L) than the normative values (>30 nmol/L). Eleven patients had sufficient values and only 4 had optimal, while 19 showed insufficient, 18 critical, and 17 severely critical levels. No differences emerged according to different socio-demographic or clinical features. In our opinion, the present findings strengthen previous research highlighting decreased vitamin D levels in bipolar patients and support the role of this pleiotropic hormone in BDs. Nevertheless, further studies should follow to corroborate the data of this preliminary study and to address the potential benefits of vitamin D supplementation in the treatment of MDs.https://www.mdpi.com/2075-1729/13/4/883vitamin Dbiomarkersmood disordersbipolar disorderstreatment resistanceaugmentation strategies |
| spellingShingle | Donatella Marazziti Paola Mangiapane Manuel Glauco Carbone Florinda Morana Alessandro Arone Lucia Massa Stefania Palermo Miriam Violi Giovanni Bertini Leonardo Massoni Sara Fantasia Andrea Pozza Federico Mucci Benedetto Morana Decreased Levels of Vitamin D in Bipolar Patients Life vitamin D biomarkers mood disorders bipolar disorders treatment resistance augmentation strategies |
| title | Decreased Levels of Vitamin D in Bipolar Patients |
| title_full | Decreased Levels of Vitamin D in Bipolar Patients |
| title_fullStr | Decreased Levels of Vitamin D in Bipolar Patients |
| title_full_unstemmed | Decreased Levels of Vitamin D in Bipolar Patients |
| title_short | Decreased Levels of Vitamin D in Bipolar Patients |
| title_sort | decreased levels of vitamin d in bipolar patients |
| topic | vitamin D biomarkers mood disorders bipolar disorders treatment resistance augmentation strategies |
| url | https://www.mdpi.com/2075-1729/13/4/883 |
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